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Neuroblastoma Stage 4 Life Expectancy Calculator

Neuroblastoma Stage 4: Prognosis and Survival Factors

Neuroblastoma is an aggressive pediatric cancer that arises from immature nerve cells, primarily affecting infants and young children. Stage 4 neuroblastoma indicates metastatic disease, meaning the cancer has spread to distant lymph nodes, bones, bone marrow, liver, or other organs. Prognosis varies significantly based on multiple clinical, genetic, and treatment-related factors.

This article explains:

• Key terms related to neuroblastoma prognosis
• How survival rates are calculated
• Factors influencing outcomes
• How our free survival calculator works
• Interpreting your results

Key Terms in Neuroblastoma Prognosis

1. Neuroblastoma Staging (INSS & INRG Systems)

Neuroblastoma is categorized into stages based on tumor spread:

• Stage 1: Localized tumor, completely removable.
• Stage 2: Localized but not fully removable.
• Stage 3: Tumor crosses midline, unresectable.
• Stage 4: Distant metastasis (high-risk).
• Stage 4S: Special category in infants with limited spread.

2. High-Risk vs. Low-Risk Neuroblastoma

Risk stratification depends on:
✔ Age at diagnosis (<18 months = better prognosis)
✔ MYCN amplification (strong predictor of aggressiveness)
✔ Tumor histology (favorable vs. unfavorable)
✔ DNA ploidy (hyperdiploid = better outcome)

3. Critical Prognostic Markers

Factor	Favorable	Unfavorable
MYCN Status	Non-amplified	Amplified
Age	<18 months	>5 years
Histology	Differentiated	Undifferentiated
Ploidy	Hyperdiploid	Diploid
LDH Levels	<1500 U/L	>1500 U/L
Ferritin Levels	<142 ng/mL	>142 ng/mL

How the Neuroblastoma Survival Calculator Works

Our free neuroblastoma stage 4 survival calculator estimates 5-year survival probability based on:

1. Patient Demographics

• Age at diagnosis (months)
• Gender (minor influence)

2. Tumor Characteristics

• Primary tumor site (adrenal vs. non-adrenal)
• Tumor size (larger = worse prognosis)
• Histology (favorable vs. unfavorable)

3. Biological & Genetic Factors

• MYCN amplification status (most critical)
• DNA ploidy (hyperdiploid vs. diploid)
• Chromosomal abnormalities (1p deletion, 11q deletion)

4. Disease Spread & Metastasis

• Number of metastatic sites (more sites = worse outcome)
• Bone/bone marrow involvement (common in stage 4)

5. Treatment Response

• Chemotherapy response (complete vs. partial remission)
• Stem cell transplant success
• Immunotherapy (anti-GD2) effectiveness

Interpreting Your Neuroblastoma Survival Estimate

After entering all relevant data, the calculator provides:

1. 5-Year Survival Probability (%)

• ≥75% (Green Zone): Favorable prognosis (young age, no MYCN amplification, good response to treatment).
• 30-74% (Yellow Zone): Intermediate risk.
• <30% (Red Zone): High-risk disease (MYCN amplified, older age, poor treatment response).

2. Risk Level Breakdown

• Low Risk: Likely long-term survival with current therapies.
• Intermediate Risk: May benefit from clinical trials.
• High Risk: Requires aggressive treatment (immunotherapy, targeted therapy).

3. Key Contributing Factors

The report highlights which factors most impact prognosis, such as:
✔ MYCN amplification (reduces survival by 30-50%)
✔ Age >5 years (worse than infants)
✔ Poor treatment response (progressive disease)

Why Use This Neuroblastoma Prognosis Calculator?

• Personalized estimate based on real clinical data.
• Helps in treatment discussions with oncologists.
• Identifies high-risk factors needing intervention.
• Free, instant, and confidential.

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