Cart is emptyChildhood Neuroblastoma Risk Calculator
A comprehensive tool to assess neuroblastoma risk factors and provide personalized insights
Neuroblastoma Risk Assessment
Risk Interpretation
Based on the clinical information provided, your child’s neuroblastoma risk assessment indicates a moderate risk classification.
This risk level suggests that:
- Close monitoring and regular follow-up are recommended
- Treatment may involve a combination of surgery and chemotherapy
- The 5-year survival rate is estimated between 75-90%
- Genetic counseling may be beneficial
Recommendations
- Consult with a pediatric oncologist for comprehensive evaluation
- Schedule regular imaging tests (CT/MRI) every 3 months
- Monitor for symptoms progression: abdominal swelling, bone pain, fever
- Consider genetic testing for familial neuroblastoma predisposition
- Maintain nutritional support and immune-boosting diet
Disclaimer: This assessment is based on standard clinical parameters and does not replace professional medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment planning.
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Childhood Neuroblastoma Risk Calculator
Table Of Contents
Childhood Neuroblastoma: Risk Factors & Prognosis
Neuroblastoma is one of the most common extracranial solid tumors in children, accounting for 6-10% of all pediatric cancers. It arises from immature nerve cells (neuroblasts) and primarily affects infants and young children, with 90% of cases diagnosed before age 5.
This aggressive cancer varies widely in behavior—some tumors spontaneously regress, while others metastasize rapidly. To help clinicians and parents assess risk, we’ve developed a comprehensive Childhood Neuroblastoma Risk Calculator that evaluates tumor biology, staging, and clinical factors to predict prognosis and guide treatment decisions.
Key Factors in Childhood Neuroblastoma Risk Calculator
Our calculator evaluates multiple semantic terms and clinical parameters critical in neuroblastoma prognosis:
1. Patient Demographics
- Age at Diagnosis (Infants <18 months have better outcomes)
- Gender (Slightly more common in males)
- Ethnicity (Some genetic predispositions exist)
2. Tumor Characteristics
- Primary Tumor Site (Adrenal gland vs. sympathetic ganglia)
- Tumor Size (Larger tumors indicate higher risk)
- INSS Stage (International Neuroblastoma Staging System)
- Image-Defined Risk Factors (IDRFs) (Surgical resectability)
3. Biological Markers (Critical for Risk Stratification)
- MYCN Amplification (Strong predictor of aggressive disease)
- DNA Ploidy (Hyperdiploidy favors better prognosis)
- Histology (Schwannian stroma-rich vs. stroma-poor)
- Chromosomal Aberrations (1p/11q deletions worsen prognosis)
4. Serum Markers & Treatment Response
- Serum Ferritin & LDH (Higher levels indicate poor prognosis)
- Neuron-Specific Enolase (NSE) (Tumor burden marker)
- Response to Chemotherapy/Surgery (Complete vs. partial response)
How the Childhood Neuroblastoma Risk Calculator Works
Our tool calculates a risk score (0-100) based on:
✅ Low Risk (Score <30) – Excellent prognosis with >95% 5-year survival; may require surgery alone.
✅ Intermediate Risk (Score 30-59) – 85-90% survival; needs chemotherapy + surgery.
✅ High Risk (Score ≥60) – Poor prognosis (~50% survival); requires intensive chemo, radiation, immunotherapy, and stem cell transplant.
Example Calculation:
| Factor | Points |
|---|---|
| Age: 24 months | +20 |
| Stage 4 | +40 |
| MYCN Amplified | +35 |
| Unfavorable Histology | +20 |
| Total Score | 115 (Capped at 100 – High Risk) |
Interpreting Your Results
After entering data, the calculator provides:
📊 Risk Meter (Color-Coded) – Visual indicator of low (green), intermediate (yellow), or high (red) risk.
📝 Personalized Recommendations – Treatment options based on risk category.
📑 Downloadable PDF Report – For medical records or specialist consultations.
Why Use This Neuroblastoma Risk Assessment Tool?
🔹 Evidence-Based Scoring – Aligns with COG (Children’s Oncology Group) and INRG (International Neuroblastoma Risk Group) guidelines.
🔹 Helps Guide Treatment Decisions – Identifies whether minimal therapy or aggressive intervention is needed.
🔹 Improves Prognostic Accuracy – Combines clinical + biological factors for better risk prediction.
Final Thoughts
Early risk assessment is critical in neuroblastoma management. Our free Childhood Neuroblastoma Risk Calculator helps parents and oncologists evaluate prognosis and make informed treatment choices.
📥 Try the calculator now and download your personalized report!
FAQs
What is the most important factor in neuroblastoma prognosis?
MYCN amplification status is the strongest predictor of aggressive disease.
Can low-risk neuroblastoma go away without treatment?
Yes, some stage 4S tumors in infants spontaneously regress.
How accurate is this calculator?
It follows established risk stratification models but should be used alongside medical consultation.
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