// Wait for DOM to be fully loaded document.addEventListener(‘DOMContentLoaded’, function() { // Form elements const form = document.getElementById(‘neuroblastoma-form’); const resultContainer = document.getElementById(‘result-container’); const calculateBtn = document.getElementById(‘calculate-btn’); const generatePdfBtn = document.getElementById(‘generate-pdf’); // Slider value display const painLevelSlider = document.getElementById(‘pain-level’); const painLevelValue = document.getElementById(‘pain-level-value’); // Result elements const survivalProbability = document.getElementById(‘survival-probability’); const riskIndicator = document.getElementById(‘risk-indicator’); const riskLevelText = document.getElementById(‘risk-level-text’); const riskLevelBar = document.getElementById(‘risk-level-bar’); const interpretationText = document.getElementById(‘interpretation-text’); const keyFactorsList = document.getElementById(‘key-factors’); // Social sharing buttons const facebookShare = document.getElementById(‘facebook-share’); const twitterShare = document.getElementById(‘twitter-share’); const linkedinShare = document.getElementById(‘linkedin-share’); const whatsappShare = document.getElementById(‘whatsapp-share’); // Update slider value display painLevelSlider.addEventListener(‘input’, function() { painLevelValue.textContent = this.value; }); // Form submission form.addEventListener(‘submit’, function(e) { e.preventDefault(); calculatePrognosis(); }); // Calculate prognosis function function calculatePrognosis() { // Show loading state calculateBtn.disabled = true; calculateBtn.innerHTML = ‘ Calculating…’; // Simulate calculation delay (in a real app, this would be immediate) setTimeout(function() { // Get form values const age = parseInt(document.getElementById(‘patient-age’).value); const mycnStatus = document.getElementById(‘mycn-status’).value; const ploidy = document.getElementById(‘ploidy’).value; const histology = document.getElementById(‘histology’).value; const ferritin = parseInt(document.getElementById(‘ferritin’).value) || 0; const ldh = parseInt(document.getElementById(‘ldh’).value) || 0; const response = document.getElementById(‘response’).value; const performanceStatus = parseInt(document.getElementById(‘performance-status’).value) || 0; // Calculate base score (simplified for demo) let score = 50; // Base 50% for stage 4 // Age factor (<18 months better prognosis) if (age < 18) score += 15; else if (age 142) score -= 10; if (ldh > 1500) score -= 10; // Treatment response if (response === ‘complete’) score += 20; else if (response === ‘very-good’) score += 15; else if (response === ‘partial’) score += 5; else if (response === ‘progressive’) score -= 20; // Performance status if (performanceStatus >= 80) score += 5; else if (performanceStatus >= 50) score -= 5; else score -= 15; // Ensure score is within bounds score = Math.max(5, Math.min(95, score)); // Display results displayResults(score); // Reset button calculateBtn.disabled = false; calculateBtn.innerHTML = ‘ Calculate Life Expectancy’; }, 1000); } // Display results function function displayResults(score) { // Round score to nearest whole number score = Math.round(score); // Update display elements survivalProbability.textContent = score + ‘%’; // Set risk indicator position (0% = left, 100% = right) const indicatorPosition = (100 – score) + ‘%’; riskIndicator.style.left = indicatorPosition; // Set risk level text and color let riskLevel, riskColor; if (score >= 75) { riskLevel = ‘Favorable’; riskColor = ‘#4caf50’; // Green } else if (score >= 30) { riskLevel = ‘Intermediate’; riskColor = ‘#ff9800’; // Orange } else { riskLevel = ‘Unfavorable’; riskColor = ‘#f44336’; // Red } riskLevelText.textContent = riskLevel; riskLevelBar.style.backgroundColor = riskColor; riskLevelBar.style.width = score + ‘%’; // Update interpretation text let interpretation = ”; if (score >= 75) { interpretation = `The estimated 5-year survival probability of ${score}% is in the favorable range for stage 4 neuroblastoma. This suggests a better-than-average prognosis compared to typical stage 4 cases. Factors contributing to this more favorable outlook may include younger age at diagnosis, absence of MYCN amplification, and good response to initial treatment.`; } else if (score >= 30) { interpretation = `The estimated 5-year survival probability of ${score}% is in the intermediate range for stage 4 neuroblastoma. This suggests a prognosis that is typical for this stage of disease. Some favorable factors may be present, but they are balanced by higher-risk features.`; } else { interpretation = `The estimated 5-year survival probability of ${score}% is in the unfavorable range for stage 4 neuroblastoma. This suggests a more challenging prognosis, often associated with factors like MYCN amplification, older age at diagnosis, or poor response to initial treatment. However, new treatment approaches are continually being developed.`; } interpretationText.innerHTML = interpretation; // Generate key factors list generateKeyFactorsList(); // Show results resultContainer.style.display = ‘block’; // Scroll to results resultContainer.scrollIntoView({ behavior: ‘smooth’ }); } // Generate key factors list function generateKeyFactorsList() { // Clear existing list keyFactorsList.innerHTML = ”; // Get form values that might be significant const age = parseInt(document.getElementById(‘patient-age’).value); const mycnStatus = document.getElementById(‘mycn-status’).value; const ploidy = document.getElementById(‘ploidy’).value; const histology = document.getElementById(‘histology’).value; const ferritin = parseInt(document.getElementById(‘ferritin’).value) || 0; const ldh = parseInt(document.getElementById(‘ldh’).value) || 0; const response = document.getElementById(‘response’).value; const performanceStatus = parseInt(document.getElementById(‘performance-status’).value) || 0; // Add factors based on values if (age = 60) { addKeyFactor(‘Older age at diagnosis (≥5 years) – unfavorable factor’, ‘negative’); } if (mycnStatus === ‘amplified’) { addKeyFactor(‘MYCN amplification – strongly unfavorable factor’, ‘negative’); } else if (mycnStatus === ‘not-amplified’) { addKeyFactor(‘No MYCN amplification – favorable factor’, ‘positive’); } if (ploidy === ‘hyperdiploid’) { addKeyFactor(‘Hyperdiploid tumor – favorable factor’, ‘positive’); } else if (ploidy === ‘diploid’) { addKeyFactor(‘Diploid tumor – unfavorable factor’, ‘negative’); } if (histology === ‘favorable’) { addKeyFactor(‘Favorable histology – positive factor’, ‘positive’); } else if (histology === ‘unfavorable’) { addKeyFactor(‘Unfavorable histology – negative factor’, ‘negative’); } if (ferritin > 142) { addKeyFactor(‘Elevated serum ferritin – unfavorable factor’, ‘negative’); } if (ldh > 1500) { addKeyFactor(‘Elevated LDH – suggests high tumor burden’, ‘negative’); } if (response === ‘complete’ || response === ‘very-good’) { addKeyFactor(‘Good response to initial treatment – favorable factor’, ‘positive’); } else if (response === ‘progressive’) { addKeyFactor(‘Progressive disease despite treatment – unfavorable factor’, ‘negative’); } if (performanceStatus >= 80) { addKeyFactor(‘Good performance status – positive factor’, ‘positive’); } else if (performanceStatus < 50) { addKeyFactor('Poor performance status – negative factor', 'negative'); } // If no factors were added (shouldn't happen with required fields) if (keyFactorsList.children.length === 0) { addKeyFactor('Multiple clinical factors were considered in this assessment', 'neutral'); } } // Add a key factor to the list function addKeyFactor(text, type) { const li = document.createElement('li'); // Add icon based on factor type let iconClass; if (type === 'positive') { iconClass = 'fas fa-plus-circle'; li.style.color = '#4caf50'; } else if (type === 'negative') { iconClass = 'fas fa-minus-circle'; li.style.color = '#f44336'; } else { iconClass = 'fas fa-info-circle'; li.style.color = '#2196f3'; } li.innerHTML = ` ${text}`; keyFactorsList.appendChild(li); } // Generate PDF report generatePdfBtn.addEventListener(‘click’, function() { // Get patient information const patientName = document.getElementById(‘patient-name’).value || ‘Not provided’; const patientAge = document.getElementById(‘patient-age’).value; const gender = document.querySelector(‘input[name=”gender”]:checked’).value; // Format gender for display let genderDisplay; switch(gender) { case ‘male’: genderDisplay = ‘Male’; break; case ‘female’: genderDisplay = ‘Female’; break; default: genderDisplay = ‘Not specified’; } // Get current date and time const now = new Date(); const dateTime = now.toLocaleString(); // Create a temporary div to hold the PDF content const pdfContent = document.createElement(‘div’); pdfContent.style.padding = ’20px’; pdfContent.style.fontFamily = ‘Arial, sans-serif’; pdfContent.style.maxWidth = ‘800px’; pdfContent.style.margin = ‘0 auto’; // Add header const header = document.createElement(‘div’); header.style.display = ‘flex’; header.style.justifyContent = ‘space-between’; header.style.alignItems = ‘center’; header.style.marginBottom = ’20px’; header.style.borderBottom = ‘2px solid #005b96′; header.style.paddingBottom = ’10px’; const logo = document.createElement(‘div’); logo.innerHTML = ‘

Neuroblastoma Prognosis Report

‘; const contact = document.createElement(‘div’); contact.style.textAlign = ‘right’; contact.style.fontSize = ’12px’; contact.innerHTML = `

Website: doseway.com

Email: support@doseway.com

WhatsApp: +92318-6144650

`; header.appendChild(logo); header.appendChild(contact); pdfContent.appendChild(header); // Add patient info section const patientInfo = document.createElement(‘div’); patientInfo.style.marginBottom = ’20px’; patientInfo.innerHTML = `

Patient Information

Name:	${patientName}
Age at Diagnosis:	${patientAge} months
Gender:	${genderDisplay}
Assessment Date:	${dateTime}

`; pdfContent.appendChild(patientInfo); // Add clinical factors section const clinicalFactors = document.createElement(‘div’); clinicalFactors.style.marginBottom = ’20px’; clinicalFactors.innerHTML = `

Clinical Factors

MYCN Status:	${document.getElementById(‘mycn-status’).options[document.getElementById(‘mycn-status’).selectedIndex].text}
DNA Ploidy:	${document.getElementById(‘ploidy’).options[document.getElementById(‘ploidy’).selectedIndex].text}
Tumor Histology:	${document.getElementById(‘histology’).options[document.getElementById(‘histology’).selectedIndex].text}
Serum Ferritin:	${document.getElementById(‘ferritin’).value || ‘Not provided’} ng/mL
Serum LDH:	${document.getElementById(‘ldh’).value || ‘Not provided’} U/L
Treatment Response:	${document.getElementById(‘response’).options[document.getElementById(‘response’).selectedIndex].text}
Performance Status:	${document.getElementById(‘performance-status’).options[document.getElementById(‘performance-status’).selectedIndex].text}

`; pdfContent.appendChild(clinicalFactors); // Add results section const resultsSection = document.createElement(‘div’); resultsSection.style.marginBottom = ’20px’; resultsSection.innerHTML = `

Prognosis Assessment

`; pdfContent.appendChild(resultsSection); // Add disclaimer const disclaimer = document.createElement(‘div’); disclaimer.style.fontSize = ’12px’; disclaimer.style.color = ‘#666′; disclaimer.style.marginTop = ’20px’; disclaimer.style.borderTop = ‘1px solid #ddd’; disclaimer.style.paddingTop = ’10px’; disclaimer.innerHTML = `

Disclaimer: This report provides statistical estimates only and should not replace professional medical advice. Individual prognosis may vary based on many factors not captured in this assessment. Always consult with your oncologist for personalized medical guidance.

Report generated on ${dateTime} by DoseWay Neuroblastoma Prognosis Calculator

`; pdfContent.appendChild(disclaimer); // Add footer const footer = document.createElement(‘div’); footer.style.marginTop = ’20px’; footer.style.paddingTop = ’10px’; footer.style.borderTop = ‘2px solid #005b96′; footer.style.fontSize = ’10px’; footer.style.textAlign = ‘center’; footer.style.color = ‘#666’; footer.innerHTML = `

© ${now.getFullYear()} DoseWay.com | support@doseway.com | WhatsApp: +92318-6144650

`; pdfContent.appendChild(footer); // Use html2canvas to capture the content html2canvas(pdfContent, { scale: 2, logging: false, useCORS: true, allowTaint: true }).then(canvas => { // Create PDF const { jsPDF } = window.jspdf; const pdf = new jsPDF(‘p’, ‘mm’, ‘a4’); const imgData = canvas.toDataURL(‘image/png’); const imgWidth = 210; // A4 width in mm const pageHeight = 295; // A4 height in mm const imgHeight = canvas.height * imgWidth / canvas.width; let heightLeft = imgHeight; let position = 0; pdf.addImage(imgData, ‘PNG’, 0, position, imgWidth, imgHeight); heightLeft -= pageHeight; // Add additional pages if needed while (heightLeft >= 0) { position = heightLeft – imgHeight; pdf.addPage(); pdf.addImage(imgData, ‘PNG’, 0, position, imgWidth, imgHeight); heightLeft -= pageHeight; } // Save the PDF pdf.save(`Neuroblastoma_Prognosis_Report_${patientName || ‘Anonymous’}_${now.getTime()}.pdf`); }); }); // Social sharing functionality facebookShare.addEventListener(‘click’, function(e) { e.preventDefault(); const url = encodeURIComponent(window.location.href); const text = encodeURIComponent(`My neuroblastoma prognosis assessment result: ${survivalProbability.textContent} 5-year survival probability.`); window.open(`https://www.facebook.com/sharer/sharer.php?u=${url}&quote=${text}`, ‘_blank’); }); twitterShare.addEventListener(‘click’, function(e) { e.preventDefault(); const text = encodeURIComponent(`Neuroblastoma prognosis assessment: ${survivalProbability.textContent} 5-year survival probability`); const url = encodeURIComponent(window.location.href); window.open(`https://twitter.com/intent/tweet?text=${text}&url=${url}`, ‘_blank’); }); linkedinShare.addEventListener(‘click’, function(e) { e.preventDefault(); const url = encodeURIComponent(window.location.href); const title = encodeURIComponent(‘Neuroblastoma Prognosis Assessment’); const summary = encodeURIComponent(`My assessment result: ${survivalProbability.textContent} 5-year survival probability.`); window.open(`https://www.linkedin.com/shareArticle?mini=true&url=${url}&title=${title}&summary=${summary}`, ‘_blank’); }); whatsappShare.addEventListener(‘click’, function(e) { e.preventDefault(); const text = encodeURIComponent(`My neuroblastoma prognosis assessment result: ${survivalProbability.textContent} 5-year survival probability. Check it out: ${window.location.href}`); window.open(`https://wa.me/?text=${text}`, ‘_blank’); }); // Form validation form.addEventListener(‘change’, function() { // Simple validation – check if required fields are filled const requiredFields = form.querySelectorAll(‘[required]’); let allValid = true; requiredFields.forEach(field => { if (!field.value) { allValid = false; } }); calculateBtn.disabled = !allValid; }); // Initialize form validation const event = new Event(‘change’); form.dispatchEvent(event); });

Try More Free Tools:

• Try Our Neuroblastoma Signs And Symptoms Checker
• Try Our Childhood Neuroblastoma Risk Calculator
• Try Our Neuroblastoma Risk Stratification Tool

Neuroblastoma Stage 4 Life Expectancy Calculator

Neuroblastoma Stage 4: Prognosis and Survival Factors

Neuroblastoma is an aggressive pediatric cancer that arises from immature nerve cells, primarily affecting infants and young children. Stage 4 neuroblastoma indicates metastatic disease, meaning the cancer has spread to distant lymph nodes, bones, bone marrow, liver, or other organs. Prognosis varies significantly based on multiple clinical, genetic, and treatment-related factors.

This article explains:

• Key terms related to neuroblastoma prognosis
• How survival rates are calculated
• Factors influencing outcomes
• How our free survival calculator works
• Interpreting your results

Key Terms in Neuroblastoma Prognosis

1. Neuroblastoma Staging (INSS & INRG Systems)

Neuroblastoma is categorized into stages based on tumor spread:

• Stage 1: Localized tumor, completely removable.
• Stage 2: Localized but not fully removable.
• Stage 3: Tumor crosses midline, unresectable.
• Stage 4: Distant metastasis (high-risk).
• Stage 4S: Special category in infants with limited spread.

2. High-Risk vs. Low-Risk Neuroblastoma

Risk stratification depends on:
✔ Age at diagnosis (<18 months = better prognosis)
✔ MYCN amplification (strong predictor of aggressiveness)
✔ Tumor histology (favorable vs. unfavorable)
✔ DNA ploidy (hyperdiploid = better outcome)

3. Critical Prognostic Markers

Factor	Favorable	Unfavorable
MYCN Status	Non-amplified	Amplified
Age	<18 months	>5 years
Histology	Differentiated	Undifferentiated
Ploidy	Hyperdiploid	Diploid
LDH Levels	<1500 U/L	>1500 U/L
Ferritin Levels	<142 ng/mL	>142 ng/mL

How the Neuroblastoma Survival Calculator Works

Our free neuroblastoma stage 4 survival calculator estimates 5-year survival probability based on:

1. Patient Demographics

• Age at diagnosis (months)
• Gender (minor influence)

2. Tumor Characteristics

• Primary tumor site (adrenal vs. non-adrenal)
• Tumor size (larger = worse prognosis)
• Histology (favorable vs. unfavorable)

3. Biological & Genetic Factors

• MYCN amplification status (most critical)
• DNA ploidy (hyperdiploid vs. diploid)
• Chromosomal abnormalities (1p deletion, 11q deletion)

4. Disease Spread & Metastasis

• Number of metastatic sites (more sites = worse outcome)
• Bone/bone marrow involvement (common in stage 4)

5. Treatment Response

• Chemotherapy response (complete vs. partial remission)
• Stem cell transplant success
• Immunotherapy (anti-GD2) effectiveness

Interpreting Your Neuroblastoma Survival Estimate

After entering all relevant data, the calculator provides:

1. 5-Year Survival Probability (%)

• ≥75% (Green Zone): Favorable prognosis (young age, no MYCN amplification, good response to treatment).
• 30-74% (Yellow Zone): Intermediate risk.
• <30% (Red Zone): High-risk disease (MYCN amplified, older age, poor treatment response).

2. Risk Level Breakdown

• Low Risk: Likely long-term survival with current therapies.
• Intermediate Risk: May benefit from clinical trials.
• High Risk: Requires aggressive treatment (immunotherapy, targeted therapy).

3. Key Contributing Factors

The report highlights which factors most impact prognosis, such as:
✔ MYCN amplification (reduces survival by 30-50%)
✔ Age >5 years (worse than infants)
✔ Poor treatment response (progressive disease)

Why Use This Neuroblastoma Prognosis Calculator?

• Personalized estimate based on real clinical data.
• Helps in treatment discussions with oncologists.
• Identifies high-risk factors needing intervention.
• Free, instant, and confidential.

FAQs