Pain and fever can strike at the most inconvenient times—whether it’s a throbbing headache, intense menstrual cramps, or post-surgery discomfort. That’s where Brufen DUO Tablet comes into play.
Known for its fast and effective relief, this medicine has become a trusted name in many households across Pakistan. But before you reach for it, it’s important to understand what Brufen DUO is, how it works, what side effects it may have, and whether it’s the right choice for you.
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Brufen DUO Tablet Uses – Brufen DUO Price, Uses, Side Effects

Table Of Contents
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What is Brufen DUO?
Brufen DUO Tablet
Brufen DUO Tablet combines ibuprofen and paracetamol to effectively relieve pain, reduce fever, and ease inflammation. It is commonly used for headaches, menstrual cramps, arthritis, and muscle pain.
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Brufen DUO is a powerful combination pain-relief medication designed to tackle both pain and inflammation effectively. It’s part of the NSAID family (Non-Steroidal Anti-Inflammatory Drugs) and is often prescribed for conditions like:
- Headaches and migraines
- Toothaches
- Joint and muscle pain
- Menstrual cramps
- Fever
- Post-surgery pain
- Pain due to injuries or chronic inflammatory conditions like arthritis
What makes it “DUO” is its unique combination of two active ingredients:
- Ibuprofen – an anti-inflammatory that reduces swelling and pain
- Paracetamol (Acetaminophen) – a painkiller and fever reducer
Brand Name & Manufacturer
- Brand Name: Brufen DUO
- Manufactured by: Abbott Laboratories, a trusted name in the global pharmaceutical industry. Abbott is well-known for producing reliable and effective medications used worldwide.
Type of Medicine
- Prescription Type: Yes (usually prescribed by doctors)
- Drug Class: NSAID (Non-Steroidal Anti-Inflammatory Drug) + Analgesic
- Common Forms Available:
- Brufen DUO Tablets – widely used for moderate to severe pain
- Brufen DUO Syrup – ideal for children or adults who struggle with swallowing tablets (less commonly used but available)
Who should use Brufen DUO?
- Every day people deal with regular or chronic pain
- Patients suffering from high fever
- Women with severe menstrual cramps
- Those recovering from dental procedures or surgeries
- Anyone curious about safe and effective pain relief options
Brufen DUO Tablet Formula
Brufen DUO Tablet is a combination medicine used for quick relief from pain, inflammation, and fever. It’s commonly prescribed for a variety of conditions, including body aches, joint pain, menstrual cramps, headaches, and fever caused by infections.
Composition: What’s Inside Brufen DUO?
Brufen DUO combines two powerful ingredients:
- Ibuprofen
- A Non-Steroidal Anti-Inflammatory Drug (NSAID)
- Reduces inflammation, swelling, and pain
- Commonly used for arthritis, muscle aches, dental pain, and back pain
- Paracetamol (also known as Acetaminophen)
- A widely used analgesic (pain reliever) and antipyretic (fever reducer)
- Helps lower fever and enhances the pain-relieving effect of ibuprofen
- Gentle on the stomach compared to other painkillers
Drug Classification
Brufen DUO falls under two main categories:
- NSAID (Non-Steroidal Anti-Inflammatory Drug) – because of Ibuprofen
- Analgesic/Antipyretic – because of Paracetamol
Available Strengths & Forms
Form | Strength (Typical) | Use |
---|---|---|
Tablet | Ibuprofen 400mg + Paracetamol 325mg | Most common used by adults |
Syrup | Varies (usually child-safe doses) | For children or adults with swallowing difficulty |
Is Brufen DUO an Antibiotic?
No, Brufen DUO is not an antibiotic. It doesn’t kill bacteria or treat infections directly.
Instead, it helps reduce pain, inflammation, and fever that may be caused by an infection. If an infection is present, it’s usually prescribed alongside an antibiotic, not as a replacement.
Brufen DUO vs Plain Brufen – What’s the Difference?
Feature | Brufen DUO | Plain Brufen |
---|---|---|
Active Ingredients | Ibuprofen + Paracetamol | Only Ibuprofen |
Pain Relief Power | Dual-action (pain + fever + anti-inflammatory) | Single-action (pain + anti-inflammatory only) |
Fever Control | Yes (due to Paracetamol) | No |
Strength | Slightly stronger due to the combination | Milder compared to DUO |
Use Cases | Moderate to severe pain, fever, menstrual cramps | Mild to moderate pain, inflammation |
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Brufen DUO Tablet Uses
- Pain Relief (Mild to Moderate):
- Ideal for body aches, muscle pain, joint pain, and post-surgery discomfort.
- Fever Reduction:
- Thanks to the Paracetamol content, it helps bring down a high fever quickly.
- Inflammatory Conditions:
- Used for chronic conditions like:
- Rheumatoid arthritis (including juvenile forms like Still’s disease)
- Ankylosing spondylitis
- Osteoarthritis
- Other non-rheumatoid joint disorders (seronegative arthropathies)
- Used for chronic conditions like:
- Dental Pain:
- Commonly prescribed after tooth extractions or dental procedures to reduce swelling and pain.
- Menstrual Cramps:
- Highly effective in relieving period pain.
Note: Brufen DUO can ease cramps, but it does not stop periods.
- Highly effective in relieving period pain.
- Back Pain & Muscle Pain:
- Whether it’s from bad posture, injury, or overexertion, Brufen DUO helps reduce inflammation and relax muscles.
- Headaches & Migraines:
- Helps in relieving tension headaches and mild migraines.
- Comparison — Brufen vs Brufen DUO vs Brufen 200/400/600:
- Brufen DUO = Ibuprofen + Paracetamol → More powerful for pain + fever
- Brufen 200/400/600 = Ibuprofen only → Focuses on inflammation and pain, less effect on fever
- DUO is better when fever + pain are both present.
- Plain Brufen (any strength) is enough for simple pain or mild inflammation.
- Used in Viral Fever or Flu?
- Yes. While Brufen DUO doesn’t treat the virus itself, it’s often used to manage body aches, fever, and discomfort caused by viral infections like the flu.
- Is Brufen Good for Stomach Pain?
- Not recommended.
- Brufen DUO can irritate the stomach lining and may make stomach pain worse, especially in ulcers, gastritis, or acid reflux.
It’s best to consult a doctor before taking it for abdominal pain.
- Brufen DUO can irritate the stomach lining and may make stomach pain worse, especially in ulcers, gastritis, or acid reflux.
- Not recommended.
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How Brufen DUO Works (Mechanism of Action)

- How Ibuprofen Works:
- Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID).
It blocks the production of prostaglandins—chemicals in the body that cause inflammation, swelling, and pain. - By reducing prostaglandins, ibuprofen relieves pain and reduces inflammation in joints, muscles, and tissues.
- Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID).
- How Paracetamol Works:
- Paracetamol works mainly in the brain and spinal cord to block pain signals.
- It also acts on the brain’s temperature control center to reduce fever.
- Unlike ibuprofen, it doesn’t reduce inflammation much, but it’s gentler on the stomach.
- Combined Effectiveness (Synergistic Action):
- When combined in Brufen DUO, ibuprofen and paracetamol work better together than alone.
- Ibuprofen targets the root cause of pain (inflammation)
- Paracetamol quickly reduces pain and fever
- This combo provides stronger and longer-lasting relief, especially helpful for severe headaches, arthritis, or post-operative pain.
- When combined in Brufen DUO, ibuprofen and paracetamol work better together than alone.
- Is Brufen Stronger Than Paracetamol?
- Yes, Brufen (ibuprofen) is generally stronger for reducing inflammation-related pain (like arthritis or sprains).
- But it may also cause more stomach upset.
- Paracetamol is milder, preferred for fever, mild pain, and people with sensitive stomachs.
- Ibuprofen vs Paracetamol: Which Is Better?
- It depends on the condition:
- For inflammation + pain, → Ibuprofen is more effective
- For fever or headache → Paracetamol is often enough
- For strong pain + fever together → The combo in Brufen DUO is usually the best option
- It depends on the condition:
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Brufen DUO Dosage Guidelines
Form & Strength | Recommended Dosage | Usage Tips & Warnings |
---|---|---|
Brufen DUO Tablet (Ibuprofen + Paracetamol) | 1 tablet every 6–8 hours as needed. Max: 3 tablets per day | Take after meals to avoid stomach irritation. Don’t use for more than 3–5 days without doctor advice. |
Brufen DUO Syrup | Dose depends on age/weight (for teens only) – consult doctor | Not suitable for small children. Safer options like Calpol (Paracetamol) or Ibuprofen suspension are recommended. |
For Fever (Adults) | 1 Brufen DUO tablet every 8 hours if fever persists | Combine with rest and fluids. Monitor temperature. Avoid exceeding the daily dose. |
Brufen 400 / 600 (Ibuprofen only) | 1 tablet every 6–8 hours as needed. Max: 3 tablets of 600mg per day | Used more for inflammatory pain. May cause gastric upset if taken on an empty stomach. |
Brufen 200mg | 1–2 tablets every 6–8 hours Max: 1200mg (6 tablets) per day | Suitable for mild pain or headache. Lower dose with fewer side effects. |
Children Use (Brufen DUO) | ❌ Not recommended for young children | Use children’s ibuprofen syrup (e.g., Nurofen) or Paracetamol drops as safer alternatives. |
Maximum Daily Dose (Adults) | Ibuprofen: 2400mg/day Paracetamol: 4000mg/day | Do not exceed—overdose can cause serious liver or kidney damage. |
Duration of Use | Safe for short-term use only: 3 to 5 days | Long-term use increases the risk of stomach ulcers, kidney issues, or liver damage. |
Can You Take It Daily? | ❌ Not recommended for everyday use without medical advice | Occasional use is okay. For daily pain, consult a doctor for safer alternatives. |
Side Effects of Brufen DUO
Common Side Effects
These are usually mild and go away on their own:
- Nausea or vomiting
- Upset stomach or indigestion
- Dizziness or light-headedness
- Drowsiness or slight sleepiness
Serious Side Effects
These are rare but require immediate medical attention:
- Liver damage (especially with overdose or long-term use)
- Kidney problems (reduced urine output, swelling, fatigue)
- Gastrointestinal bleeding (vomiting blood, black stools, severe stomach pain)
- Allergic reactions (rash, breathing difficulty, swelling of face/lips)
Who Should NOT Take Brufen DUO?
- People with active stomach ulcers or gastric bleeding
- Those with severe liver or kidney disease
- Pregnant women (especially in the third trimester) – use only if prescribed
- Anyone allergic to NSAIDs or paracetamol
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Brufen DUO Precautions
- Avoid with blood thinners (like Warfarin): Increases risk of bleeding.
- Use caution with antihypertensive medicines (like ACE inhibitors): Brufen can reduce their effectiveness.
- Avoid alcohol while taking Brufen DUO: It increases the risk of liver damage and stomach ulcers.
- Pregnant women (especially in the 3rd trimester) should avoid Brufen DUO unless prescribed by a doctor—it can harm the baby or complicate labor.
- Breastfeeding mothers should consult a doctor before using—it may pass into breast milk in small amounts.
- Elderly patients may have a higher risk of side effects like stomach bleeding or kidney issues. Use under medical supervision.
- People with asthma should be cautious—NSAIDs like ibuprofen can trigger asthma attacks in some individuals.
- Patients with gastric issues (ulcers, acid reflux, etc.) should avoid or use only with food and stomach-protective medication.
- Can Brufen be taken during periods? Yes, it can help relieve menstrual cramps and lower pain, but it does not stop periods.
- Is Brufen safe for daily use? No, long-term daily use without a doctor’s advice can cause serious liver, kidney, or stomach problems. It’s best used occasionally for pain or fever.
Brufen DUO Comparison with Other Medicines
Comparison | Brufen (Ibuprofen) | Panadol (Paracetamol) | Disprin (Aspirin) | Brufen DUO (Ibuprofen + Paracetamol) | Duo 5 vs Brufen DUO |
---|---|---|---|---|---|
Type of Medicine | NSAID (anti-inflammatory and pain relief) | Analgesic and antipyretic (fever reducer, pain relief) | NSAID and blood thinner | Combination of NSAID + Analgesic (stronger pain and fever relief) | Duo 5 is similar to Brufen DUO, both combine ibuprofen and paracetamol, but may differ in manufacturer or dosage. |
Uses | Pain, inflammation, fever, and menstrual cramps | Pain and fever relief | Pain, inflammation, fever, and blood thinning | More effective pain and fever relief than either alone | Same basic use, stronger combined effect than individual ingredients. |
Effectiveness for Fever | Good | Very effective | Good | Very effective (faster and longer-lasting) | Similar effectiveness. |
Effectiveness for Menstrual Pain | Very effective for cramps and inflammation | Effective for mild pain | Effective, but can increase bleeding risk | Most effective due to the combined action | Similar to Brufen DUO. |
Side Effects | Possible stomach upset, kidney risk | Generally safer, fewer stomach issues | Stomach irritation, bleeding risk | Combining the side effects of both ibuprofen and paracetamol | Similar side effects to Brufen DUO. |
Generic Version | Ibuprofen | Paracetamol | Aspirin | No direct generic; combo product | Duo 5 may be a branded or alternative version of Brufen DUO. |
Best for Fever | Yes, but paracetamol preferred if the stomach is sensitive | Yes, safest for fever and mild pain | Yes, but less preferred due to bleeding risk | Yes, best for fast and strong fever relief | Same as Brufen DUO. |
Best for Menstrual Pain | Yes | Yes, but less strong | Yes, but caution is advised | Best option due to combo action | Same as Brufen DUO. |
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FAQs
What is Brufen DUO used for?
Brufen DUO is used to relieve mild to moderate pain, reduce fever, and ease inflammation caused by conditions like arthritis, menstrual cramps, headaches, and muscle pain.
Is Brufen DUO an antibiotic?
No, Brufen DUO is not an antibiotic. It’s a combination of ibuprofen (an NSAID) and paracetamol, used to reduce pain and fever, not to fight infections.
Can Brufen stop periods?
No, Brufen does not stop periods. It can help reduce menstrual pain and cramps, but it won’t affect the menstrual cycle itself.
What is the safest pain reliever?
Paracetamol (like Panadol) is generally considered the safest for most people, especially those with sensitive stomachs or certain health conditions.
What organ is most affected by Ibuprofen?
Ibuprofen can affect the stomach lining, causing irritation or ulcers and may impact the kidneys if taken long-term or in high doses.
How many Brufen tablets can I take per day?
For adults, the usual dose is 1-2 tablets every 6-8 hours, not exceeding 6 tablets (usually 2400 mg ibuprofen) per day.
Is it safe to take Brufen during a fever?
Yes, Brufen DUO is effective for reducing fever and is safe when used as directed.
Is it okay to take Brufen with milk or during periods?
Taking Brufen with milk or food is recommended to protect your stomach. It is safe to take during periods for pain relief.
Can Brufen DUO be taken on an empty stomach?
It’s best to avoid taking Brufen DUO on an empty stomach to reduce the risk of stomach upset or irritation.
What pain is Brufen best for?
Brufen DUO works well for headaches, muscle pain, arthritis pain, dental pain, and menstrual cramps.
Can I drink alcohol while taking Brufen DUO?
It’s best to avoid alcohol while on Brufen DUO, as both can increase the risk of liver damage and stomach bleeding.
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Conclusion
In summary, Brufen DUO is a powerful combination tablet that effectively relieves pain, reduces fever, and tackles inflammation thanks to its ibuprofen and paracetamol content. It’s available at a reasonable price and offers flexible dosage options for adults, but it’s important to follow the recommended dose and not exceed it.
While generally safe, Brufen DUO can cause side effects like stomach upset or dizziness, and serious reactions are rare but possible. This medicine is ideal for adults experiencing mild to moderate pain, menstrual cramps, or fever.
However, it should always be used responsibly and under medical guidance. Before starting Brufen DUO, especially for long-term use or if you have underlying health issues, make sure to consult your doctor to ensure it’s the right choice for you.
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