Acefyl Syrup Uses and Price in Pakistan

Acefyl Syrup is a widely used bronchodilator medication in Pakistan, primarily prescribed for respiratory conditions like asthma, bronchitis, and persistent cough. This guide details everything you need to know about Acefyl Syrup, including its active ingredient Acefylline, correct dosage for adults and children, current market price, potential side effects, and crucial safety information for special populations such as pregnant women and diabetic patients. Understanding the proper use of this syrup is essential for effective treatment and avoiding adverse effects.

In this definitive article, you will learn:

• The primary medical uses and mechanism of Acefylline
• Accurate dosage guidelines for all age groups, from infants to adults
• Updated price information for 60ml and 125ml bottles across Pakistan
• Comprehensive analysis of side effects and drug interactions
• Safety considerations for pregnancy, diabetes, and other special conditions
• Comparisons with alternative cough syrups like Ascoril and Coferb
• Answers to frequently asked questions about cough management

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What is Acefyl Syrup? An Overview

Acefyl Syrup is a popular prescription medication in Pakistan belonging to the class of drugs known as bronchodilators. It is primarily used to treat and manage symptoms associated with obstructive airway diseases. The therapeutic effects of this syrup make it a go-to choice for physicians when dealing with persistent cough and breathing difficulties.

What is the active ingredient in Acefyl Syrup?

The active ingredient in Acefyl Syrup is Acefylline, which is a derivative of Theophylline, a methylxanthine compound. Acefylline works differently from typical antihistamine or suppressant cough syrups, targeting the underlying physiological mechanisms that cause airway constriction rather than simply suppressing the cough reflex. This fundamental difference makes it particularly effective for specific types of respiratory distress.

• Pharmaceutical Class: Methylxanthine derivative
• Chemical Structure: Similar to Theophylline but with different pharmacokinetic properties
• Primary Action: Bronchodilation and respiratory stimulation

What is the mechanism of action of Acefylline?

Acefylline operates through multiple pharmacological pathways to relieve respiratory symptoms. Understanding its mechanism of action explains why it’s prescribed for specific conditions and not for every type of cough.

• Phosphodiesterase Inhibition: Acefylline blocks the enzyme phosphodiesterase, leading to increased cyclic AMP levels, which promotes relaxation of bronchial smooth muscles
• Adenosine Receptor Antagonism: By blocking adenosine receptors, it prevents bronchoconstriction that would otherwise narrow airways
• Respiratory Stimulation: It enhances the contractility of diaphragmatic muscles, improving respiratory drive and efficiency
• Mucociliary Clearance: The drug helps in increasing the movement of cilia in the respiratory tract, facilitating the removal of mucus and secretions

Common brand names and manufacturers in Pakistan

Acefyl Syrup is manufactured by multiple pharmaceutical companies in Pakistan, with some variations in brand names and formulations. The most common manufacturers include:

• Bosch Pharmaceutical (Pakistan)
• S.J. & G. Fazul Ellahie
• Saydon Pharmaceutical
• Pharmix Pharmaceutical

Different brands may offer the syrup in varying concentrations, with Acefyl 125 containing a higher strength of the active ingredient compared to standard Acefyl syrup.

Primary Uses and Benefits of Acefyl Syrup

Acefyl Syrup is prescribed for specific respiratory conditions where airway obstruction is a primary concern. Its therapeutic benefits extend beyond simple cough suppression, addressing the root cause of breathing difficulties in obstructive lung diseases.

What is Acefylline used for?

Acefylline has several established medical applications based on its pharmacological properties as a bronchodilator and respiratory stimulant. Physicians prescribe it for:

• Bronchial Asthma: For both acute attacks and chronic management of reversible airway obstruction
• Chronic Bronchitis: To alleviate symptoms of inflammation and mucus production in the airways
• Emphysema: As part of comprehensive management for this obstructive lung disease
• COPD: Chronic Obstructive Pulmonary Disease management where airway constriction is present
• Bronchiectasis: To improve airway clearance in this chronic condition characterized by damaged airways

Is Acefyl Syrup for dry cough or wet cough?

Acefyl Syrup is effective for both dry and wet coughs, but its mechanism works best when bronchospasm is involved in the cough reflex. The classification depends on the underlying cause:

• Dry Cough: Effective when the dry cough results from bronchial constriction or irritation
• Wet Cough: Helps by improving mucus clearance through enhanced ciliary action and bronchodilation
• Spasmodic Cough: Particularly effective for coughs with a spasmodic or wheezing component

Acefyl syrup uses for babies and children

Pediatric use of Acefyl Syrup requires extreme caution and strict medical supervision. In children, it may be prescribed for:

• Asthmatic Bronchitis: When children present with wheezing and breathing difficulties
• Bronchiolitis: As part of a comprehensive treatment plan under hospital supervision
• Exercise-Induced Bronchospasm: For prevention and management in school-aged children
• Viral-Associated Wheeze: For symptomatic relief during respiratory infections

Acefyl Syrup Dosage: A Detailed Guide for All Ages

Correct dosage of Acefyl Syrup is critical for both effectiveness and safety. The appropriate dose varies significantly based on age, weight, and clinical condition. Never self-prescribe or adjust dosage without medical consultation.

Important Disclaimer: The necessity of a doctor’s prescription

Acefyl Syrup is a prescription medication that should only be used under medical supervision. The dosage information provided here is for educational reference only and does not replace professional medical advice. Incorrect dosing can lead to serious side effects, particularly in vulnerable populations.

Acefyl syrup dose for adults

For adult patients, the typical dosage of Acefyl Syrup follows these general guidelines:

• Standard Adult Dose: 10-20 ml (2-4 teaspoonfuls) two to three times daily
• Maximum Daily Dose: Should not exceed 60 ml per day without specific medical instruction
• Administration: Preferably after meals to minimize gastrointestinal side effects
• Duration: Typically prescribed for 5-7 days, with medical review for extended use

Acefyl syrup dose for child and infant populations

Pediatric dosing requires careful calculation based on body weight and must be determined by a healthcare provider. General guidelines include:

• Children 6-12 years: 5-10 ml (1-2 teaspoonfuls) two to three times daily
• Children 2-5 years: 2.5-5 ml (½-1 teaspoonful) two to three times daily
• Infants 6 months-2 years: 1.25-2.5 ml (¼-½ teaspoonful) two to three times daily

Acefyl Syrup for 2 year old

For a 2-year-old child, the typical dosage ranges from 2.5-5 ml per dose, administered two to three times daily. This should be precisely measured using an appropriate dosing syringe or spoon.

Acefyl Syrup for 3 year old

For a 3-year-old child, the dosage may range from 2.5-5 ml per dose, two to three times daily, with the exact amount determined by the child’s weight and clinical condition.

Acefyl syrup dose for 6-month old baby

For infants as young as 6 months, extreme caution is necessary. The typical dose ranges from 1.25-2.5 ml per dose, administered two to three times daily, but only under strict medical supervision.

Acefyl syrup age limit

Most manufacturers specify that Acefyl Syrup should not be used in infants below 6 months of age due to immaturity of metabolic pathways and increased risk of serious side effects.

How to measure the dose accurately?

Proper dose measurement is crucial for safety and efficacy:

• Use the measuring device provided with the medication
• Household teaspoons vary in size and should not be used
• Oral dosing syringes provide the most accurate measurement for children
• Always measure at eye level on a flat surface

How long should you take Acefyl Syrup? Can I take cough syrup daily?

The duration of Acefyl Syrup treatment depends on the condition being treated:

• Acute Conditions: Typically 5-7 days until symptoms improve
• Chronic Conditions: May require longer-term use with medical monitoring
• Daily Use: Should only be done under medical supervision with periodic assessment

Acefyl Syrup Price in Pakistan

The price of Acefyl Syrup in Pakistan varies based on manufacturer, location, pharmacy pricing policies, and bottle size. Prices are subject to change due to market factors.

Factors affecting the price of Acefyl Syrup

Several elements influence the retail price of Acefyl Syrup:

• Manufacturer Brand: Different pharmaceutical companies price their products differently
• Location: Prices may vary between cities and rural areas
• Pharmacy Type: Hospital pharmacies may have different pricing than community pharmacies
• Packaging Size: 60ml vs. 125ml bottles have different price points
• Market Competition: Areas with more pharmacies may have competitive pricing

Acefyl syrup 60ml price in Pakistan

The current price range for Acefyl Syrup 60ml in Pakistan is approximately PKR 120 to PKR 180, depending on the manufacturer and location.

Acefyl 125 syrup price in Pakistan

The Acefyl 125 syrup (125ml bottle) typically ranges from PKR 200 to PKR 300 across different regions of Pakistan.

Price comparison table: Acefyl vs. other common cough syrups

Cough Syrup	Active Ingredient	Bottle Size	Price Range (PKR)	Primary Use
Acefyl Syrup	Acefylline	60ml	120-180	Bronchodilator
Acefyl 125 Syrup	Acefylline	125ml	200-300	Bronchodilator
Ascoril Syrup	Salbutamol + Guaifenesin + Bromhexine	100ml	250-350	Expectorant/Bronchodilator
Coferb Syrup	Chlorpheniramine + Codeine	100ml	180-250	Cough Suppressant
Respira Syrup	Salbutamol + Bromhexine	100ml	220-320	Bronchodilator/Expectorant

Side Effects and Safety Profile of Acefyl Syrup

Like all medications, Acefyl Syrup can cause side effects, ranging from mild discomfort to serious adverse reactions. Understanding these potential effects helps in early recognition and appropriate management.

What are the common side effects of Acefyl Syrup?

The most frequently reported side effects of Acefylline include:

• Gastrointestinal: Nausea, vomiting, stomach pain, diarrhea
• Neurological: Headache, dizziness, restlessness, insomnia
• Cardiac: Palpitations, tachycardia (increased heart rate)
• General: Irritability, nervousness, flushing

Does Acefylline affect sleep? Can cough syrup make you sleepy?

Unlike many cough syrups that contain sedating antihistamines, Acefylline typically does not cause drowsiness. In fact, it may have the opposite effect:

• Stimulant Properties: As a xanthine derivative similar to caffeine, it may cause restlessness and insomnia
• Sleep Disturbance: Some patients report difficulty falling asleep, especially with evening doses
• Individual Variation: Response can vary, with some individuals experiencing no sleep changes

Serious side effects and when to seek immediate medical help

While uncommon, some serious side effects require immediate medical attention:

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Chest pain or irregular heartbeat
• Severe or persistent vomiting
• Seizures or convulsions
• Signs of toxicity: Extreme restlessness, confusion, severe headache

Acefyl syrup side effects for babies

Infants and young children are more vulnerable to side effects due to immature metabolism:

• Increased irritability and crying
• Sleep disturbances
• Feeding difficulties
• Rapid breathing
• Increased risk of dehydration from gastrointestinal effects

Drug Interactions

Acefyl Syrup can interact with several medications, potentially altering their effects:

• Other Bronchodilators: Concurrent use may increase the risk of adverse effects
• Antibiotics: Certain antibiotics like Erythromycin may increase Acefylline levels
• Anticonvulsants: Medications like Phenytoin may decrease Acefylline effectiveness
• Blood Thinners: May interact with Warfarin, requiring monitoring

Special Populations: Warnings and Precautions

Certain populations require special consideration when using Acefyl Syrup due to altered metabolism, potential risks, or limited safety data.

Is Acefyl syrup safe in pregnancy?

The safety of Acefyl Syrup during pregnancy has not been firmly established, and it should be used only when clearly needed:

• Risk Category: Generally categorized as requiring caution during pregnancy
• First Trimester: Particularly cautious use during early pregnancy
• Benefit-Risk Assessment: Should only be used if potential benefits outweigh potential risks

Acefyl syrup in early pregnancy

During the first trimester, when organ development occurs, medication use should be minimized. Acefyl Syrup should be avoided unless absolutely necessary and prescribed by a healthcare provider aware of the pregnancy.

Which cough syrup is safe during pregnancy in Pakistan?

For pregnant women requiring cough relief, safer alternatives may include:

• Simple linctus for dry cough
• Honey and lemon preparations (after first trimester)
• Saline nasal sprays for post-nasal drip
• Guaifenesin-based expectorants (after medical consultation)

Acefyl Syrup and Lactation

Acefylline is excreted in breast milk and may cause irritability or sleep disturbances in nursing infants. Breastfeeding mothers should consult their doctor before using this medication.

Use in patients with Liver or Kidney Disease

Patients with hepatic or renal impairment may require dosage adjustments:

• Liver Disease: Reduced metabolism may lead to accumulation and toxicity
• Kidney Disease: Impaired excretion may increase drug levels
• Monitoring: Regular monitoring of drug levels may be necessary in these patients

Use in Diabetic Patients

Diabetic patients need to consider the sugar content in cough syrups:

• Sugar Content: Standard Acefyl Syrup contains sucrose, which may affect blood glucose
• Sugar-Free Alternatives: Some manufacturers offer sugar-free versions
• Monitoring: Diabetic patients should monitor blood glucose more frequently when taking syrup medications

Is Acefyl syrup sugar free?

Standard Acefyl Syrup formulations contain sugar. However, some manufacturers may offer sugar-free versions. Patients should check the product label or consult their pharmacist.

Which cough syrup is safe for diabetic patients?

Diabetic patients have several options for cough management:

• Sugar-free formulations of various cough syrups
• Coferb sugar-free version
• Ascoril DX sugar-free
• Tablet or capsule forms of bronchodilators when appropriate

Comparisons and Alternatives to Acefyl Syrup

Understanding how Acefyl Syrup compares to other cough medications helps in making informed treatment decisions and knowing when alternatives might be more appropriate.

Acefyl Syrup vs. Ascoril Syrup

These two syrups have different compositions and indications:

• Active Ingredients: Acefyl contains Acefylline; Ascoril typically contains Salbutamol, Guaifenesin, and Bromhexine
• Primary Action: Acefyl is primarily a bronchodilator; Ascoril combines bronchodilation with expectorant action
• Indications: Acefyl for bronchospasm; Ascoril for productive cough with bronchospasm
• Side Effect Profile: Both can cause similar side effects like tremors and palpitations

Acefyl Syrup vs. Coferb Cough Syrup

These syrups have fundamentally different mechanisms:

• Acefyl: Bronchodilator that addresses airway constriction
• Coferb: Contains codeine, which suppresses the cough reflex centrally
• Use Cases: Acefyl for asthmatic/bronchitic cough; Coferb for dry, irritating cough
• Regulation: Coferb contains codeine, which has more restrictions

Acefyl Syrup vs. Respira Syrup

Respira Syrup is another combination product used for respiratory conditions:

• Respira Composition: Typically contains Salbutamol and Bromhexine
• Action: Bronchodilation with mucus liquefying action
• Comparison: Both are bronchodilators, but Respira has stronger expectorant properties

What is the best syrup for cough in Pakistan?

The “best” cough syrup depends entirely on the type of cough and underlying cause:

• Dry, Irritating Cough: Suppressants like Coferb may be appropriate
• Cough with Bronchospasm: Bronchodilators like Acefyl are indicated
• Productive Cough: Expectorants like Ascoril or Respira may be better
• Allergic Cough: Antihistamine-containing syrups might be preferred

Which cough syrup works fast?

The onset of action varies between cough syrups:

• Acefyl Syrup: Typically begins working within 30 minutes, with peak effect in 1-2 hours
• Salbutamol-based Syrups: Often have faster onset (15-30 minutes)
• Codeine-containing Syrups: May take 30-60 minutes for full suppressant effect
• Antihistamine Syrups: Usually work within 30-60 minutes

Comprehensive FAQ Section: Answering Your Queries

This section addresses common questions about Acefyl Syrup and related cough management topics, providing concise, authoritative answers.

What is the best syrup to stop coughing?

The best syrup to stop coughing depends on the cough type. For coughs with bronchospasm, bronchodilators like Acefyl work well. For dry, irritating coughs, suppressants like codeine-based syrups may be better. Productive coughs benefit from expectorants.

What are the uses of this syrup?

Acefyl Syrup is primarily used for respiratory conditions characterized by bronchospasm, including asthma, chronic bronchitis, COPD, and other obstructive airway diseases where breathing difficulty and cough are present.

Can I take cough syrup daily? What happens if you take cough syrup for more than 7 days?

Most cough syrups, including Acefyl, are intended for short-term use (5-7 days). Prolonged use without medical supervision can lead to side effects, medication tolerance, or masking of underlying conditions that need different treatment.

How to stop a cough very fast? What is the fastest cure for a cough?

For immediate cough relief: stay hydrated, use steam inhalation, try honey (for adults), avoid irritants, and use appropriate medication. The “fastest cure” depends on the cause, but bronchodilators like Acefyl work quickly for coughs with bronchospasm.

Which is the best antibiotic for cough?

Most coughs are viral and don’t require antibiotics. Bacterial infections causing cough may need antibiotics like Amoxicillin, Azithromycin, or Doxycycline, but these must be prescribed by a doctor after proper diagnosis.

Why not drink water after cough syrup? Can I drink water after cough syrup?

This is a misconception. Drinking water after cough syrup is actually beneficial as it helps hydrate the respiratory tract and can enhance the effect of expectorant medications. It does not “wash away” the medicine.

Does drinking water help with side effects?

Yes, adequate hydration can help manage some side effects of medications, particularly gastrointestinal issues. However, it doesn’t prevent all side effects and shouldn’t replace proper medical management of adverse reactions.

What can I drink to stop coughing?

Warm liquids like herbal tea with honey, warm water with lemon, or broth can soothe the throat and temporarily relieve cough. Caffeinated beverages should be limited as they may cause dehydration.

How to clear mucus?

Effective ways to clear mucus include: staying well-hydrated, using steam inhalation, trying chest physiotherapy, using expectorant medications, and avoiding dehydrating substances like caffeine and alcohol.

Why do I cough more at night?

Nighttime coughing worsens due to: post-nasal drip accumulating, reclined position allowing mucus pooling, cooler/drier air irritating airways, and reduced cortisol levels at night increasing inflammation.

Can allergies cause a dry cough?

Yes, allergic reactions commonly cause dry, persistent coughs due to post-nasal drip and airway irritation from allergens like pollen, dust mites, or pet dander.

Are cough syrups good or bad?

Cough syrups are beneficial when used appropriately for specific conditions but can be harmful if misused, overused, or used without proper diagnosis. They are tools that require knowledgeable application.

What are 5 common side effects of medications?

Common medication side effects across all drug classes include: nausea, headache, dizziness, drowsiness or insomnia, and skin rashes or reactions.

What are the side effects of Delased syrup?

Delased syrup typically contains Bromhexine and may cause side effects like gastrointestinal upset, mild headache, and rarely allergic reactions. Specific side effects depend on the exact formulation.

Is Pulmonol syrup safe in pregnancy?

The safety of Pulmonol syrup in pregnancy hasn’t been firmly established. Pregnant women should consult their doctor before using any cough medication, including Pulmonol.

Is Ascoril syrup good for kids? Is Ascoril for dry or wet cough?

Ascoril can be used in children at appropriate doses but requires medical supervision. It’s primarily for wet, productive coughs as it contains expectorants, though some formulations address dry cough too.

Can I give my 2.5 year old cough syrup?

Some cough syrups are approved for 2.5-year-olds at appropriate doses, but never give cough medication without pediatrician approval, especially under 4 years old.

How to use salbutamol syrup for kids?

Salbutamol syrup for children must be dosed precisely based on weight, typically 0.1-0.15 mg/kg per dose, not exceeding every 6-8 hours. Exact dosing should be determined by a pediatrician.

Is diphenhydramine HCl safe for kids?

Diphenhydramine is generally not recommended for young children due to potential serious side effects. For children under 4, it should only be used under direct medical advice.

Conclusion: Responsible Use of Acefyl Syrup

Acefyl Syrup is an effective bronchodilator medication for specific respiratory conditions characterized by airway constriction. When used appropriately under medical guidance, it can provide significant relief from coughing and breathing difficulties associated with asthma, bronchitis, and COPD. However, like all prescription medications, it requires careful dosing, awareness of potential side effects, and special precautions for vulnerable populations such as children, pregnant women, and patients with underlying health conditions. Always consult a healthcare professional for proper diagnosis and treatment recommendations rather than self-medicating, as the appropriate cough treatment depends entirely on the underlying cause of symptoms.