Description
Lowplat Plus Tablets 75/75mg (1 Strip = 10 Tablets)
Product Overview
Lowplat Plus 75/75mg Tablet is a prescription oral medication containing a fixed-dose combination of Clopidogrel (75mg) and Aspirin (75mg). Manufactured by a reputable pharmaceutical company in Pakistan, this advanced dual antiplatelet therapy is specifically designed for the prevention of atherothrombotic events in patients with acute coronary syndrome or a history of cardiovascular disease. Lowplat Plus works through two complementary mechanisms: clopidogrel inhibits platelet aggregation by blocking the P2Y12 receptor, while aspirin irreversibly inhibits cyclooxygenase-1 (COX-1), preventing the formation of thromboxane A2. Together, they effectively prevent dangerous blood clots, reducing the risk of heart attacks and strokes. Administered as a simple, once-daily oral tablet, Lowplat Plus offers a convenient and effective treatment option for high-risk cardiovascular patients. Each strip contains 10 tablets (75mg/75mg each) .
This advanced dual antiplatelet therapy delivers effective cardiovascular protection:
Dual Antiplatelet Action: Combines two complementary antiplatelet agents for superior prevention of blood clot formation.
Acute Coronary Syndrome Management: Indicated for the prevention of atherothrombotic events in patients with acute coronary syndrome (unstable angina, non-ST-elevation MI, or ST-elevation MI).
Secondary Prevention: Reduces the risk of cardiovascular death, myocardial infarction (heart attack), and stroke in patients with a history of cardiovascular disease.
Proven Efficacy: Dual antiplatelet therapy has been shown to be more effective than either agent alone in preventing cardiovascular events.
Once-Daily Dosing: Simple, once-daily oral administration for convenient and consistent treatment.
Prescription Medication: Requires a prescription from a qualified healthcare professional.
What are the Primary Uses and Key Features of Lowplat Plus Tablet?
Lowplat Plus Tablet serves as a specialized therapeutic solution for preventing atherothrombotic events in high-risk cardiovascular patients. It is designed to effectively reduce the risk of life-threatening blood clots through its dual antiplatelet mechanism.
Core Uses of This Medication
Acute Coronary Syndrome (ACS) Management: Indicated for the prevention of atherothrombotic events in patients with acute coronary syndrome, including unstable angina, non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI).
Recent Myocardial Infarction: For patients who have had a recent heart attack, to reduce the risk of subsequent cardiovascular events.
Recent Stroke: For patients who have had a recent stroke, to reduce the risk of subsequent cardiovascular events.
Established Peripheral Arterial Disease: For patients with established peripheral arterial disease (PAD), to reduce the risk of cardiovascular events.
Dual Antiplatelet Therapy: Used as part of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) or coronary artery stenting.
Standout Product Features
| Feature | Description |
|---|---|
| Active Ingredients | Clopidogrel (75mg) and Aspirin (75mg). |
| Strength: 75/75mg | Each tablet contains 75mg of clopidogrel and 75mg of aspirin. |
| Dual Antiplatelet Therapy | Fixed-dose combination for convenient dual antiplatelet treatment. |
| Oral Administration | Convenient once-daily tablet that can be taken with or without food. |
| Complementary Mechanism | Dual-action for superior prevention of blood clots. |
| Proven Cardiovascular Protection | Reduces the risk of heart attacks and strokes. |
| Prescription Required | Available only with a prescription from a qualified healthcare professional. |
| Blister Packaging | Each strip contains 10 tablets. |
What Key Ingredients are in Lowplat Plus Tablet and How Does It Work?
Composition
| Component | Description |
|---|---|
| Clopidogrel | Each tablet contains 75mg of clopidogrel (as clopidogrel bisulfate). |
| Aspirin | Each tablet contains 75mg of aspirin (acetylsalicylic acid). |
| Other Ingredients | Contains pharmaceutical excipients including tablet binders and coating agents. |
Mechanism of Action
Lowplat Plus combines two complementary antiplatelet agents:
Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. It selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible, and the effect lasts for the lifespan of the platelet (approximately 7-10 days).
Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, preventing the formation of thromboxane A2, a potent platelet aggregator and vasoconstrictor. By inhibiting thromboxane A2 production, aspirin reduces platelet aggregation and the risk of thrombus formation.
Together, these two mechanisms provide effective and complementary inhibition of platelet aggregation, reducing the risk of dangerous blood clots that can cause heart attacks and strokes.
Key Benefits
Reduces the risk of heart attacks, strokes, and cardiovascular death.
Prevents dangerous blood clots from forming in arteries.
Convenient once-daily fixed-dose combination.
Proven efficacy in high-risk cardiovascular patients.
Can be taken with or without food.
How Should I Use Lowplat Plus Tablet Correctly?
Lowplat Plus Tablet must be taken orally as prescribed by a healthcare professional. Do not self-adjust the dose.
Dosage and Administration
| Parameter | Details |
|---|---|
| Recommended Dose | One tablet (75mg clopidogrel / 75mg aspirin) once daily. |
| Acute Coronary Syndrome | May be initiated with a loading dose of clopidogrel (300mg) and aspirin (300mg) as directed by the physician. |
| Elderly Patients | No dose adjustment required. |
| Renal Impairment | Use with caution in patients with renal impairment. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. |
| Method of Administration | Take orally with water, with or without food. |
| Duration | Chronic therapy is typical, as prescribed by the physician. |
Method of Administration
Oral: Take the tablet orally with a glass of water.
With or Without Food: Can be taken with or without food.
Consistency: Take at the same time each day for consistent treatment.
Swallow Whole: Swallow the tablet whole; do not crush or chew.
Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Important Considerations
Prescription Only: This medication is available only with a prescription.
Pregnancy and Lactation: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
Bleeding Risk: Both clopidogrel and aspirin increase the risk of bleeding. Inform your doctor if you have a history of bleeding disorders or conditions that increase bleeding risk.
Surgery: Inform your doctor if you are scheduled for any surgery or dental procedure, as you may need to stop taking Lowplat Plus temporarily.
Monitoring: Regular monitoring may be required to assess bleeding risk and treatment response.
What Precautions Should I Be Aware of Before Taking This Medication?
While generally safe and well-tolerated, specific conditions and interactions require awareness and caution.
Key Warnings and Contraindications
Hypersensitivity: Contraindicated in patients with known hypersensitivity to clopidogrel, aspirin, or any excipients.
Active Bleeding: Contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Severe Hepatic Impairment: Contraindicated in patients with severe hepatic impairment.
Aspirin Allergy: Contraindicated in patients with aspirin allergy or asthma exacerbated by aspirin.
Bleeding Risk: Dual antiplatelet therapy significantly increases the risk of bleeding, including gastrointestinal bleeding, intracranial hemorrhage, and bleeding from minor trauma.
CYP2C19 Poor Metabolizers: Patients who are poor metabolizers of CYP2C19 may have reduced effectiveness of clopidogrel.
Thrombotic Thrombocytopenic Purpura (TTP): Rarely, clopidogrel can cause TTP, a serious condition that requires immediate medical attention.
Gastrointestinal Risk: Aspirin increases the risk of gastrointestinal ulceration and bleeding.
Recent Major Surgery: Use with caution in patients with recent major surgery or trauma.
Drug Interactions
| Interaction | Recommendation |
|---|---|
| Other Antiplatelets/Anticoagulants | Increased risk of bleeding; avoid concurrent use unless absolutely necessary. |
| NSAIDs | Increased risk of gastrointestinal bleeding; avoid concurrent use. |
| Warfarin | Increased risk of bleeding; avoid concurrent use unless absolutely necessary. |
| Omeprazole/Esomeprazole | May reduce the effectiveness of clopidogrel; consider using other acid-reducing agents. |
| SSRIs/SNRIs | Increased risk of bleeding; use with caution. |
When to Seek Immediate Medical Attention
Severe Allergic Reaction: Difficulty breathing, swelling of the face/lips/tongue/throat.
Signs of Bleeding: Unexplained or prolonged bleeding, blood in urine or stool, coughing up blood, vomiting blood.
Signs of TTP: Fever, weakness, confusion, yellowing of skin or eyes, dark urine.
Signs of Intracranial Hemorrhage: Severe headache, weakness on one side of the body, confusion, difficulty speaking.
Signs of Stroke: Sudden numbness or weakness, confusion, difficulty speaking or understanding speech, vision problems, severe headache.
Are There Any Potential Side Effects of Lowplat Plus Tablet?
As with all medications, Lowplat Plus Tablet may cause side effects, although not everyone experiences them.
Side Effects by Frequency
| Frequency | Side Effects |
|---|---|
| Common (≥1% to <10%) | Bleeding (including gastrointestinal, intracranial, and nasal bleeding), bruising, diarrhea, abdominal pain, dyspepsia, nausea, headache. |
| Uncommon (≥0.1% to <1%) | Dizziness, vomiting, skin rash, itching, thrombocytopenia, leukopenia, eosinophilia. |
| Rare (<0.1%) | Thrombotic thrombocytopenic purpura (TTP), aplastic anemia, severe thrombocytopenia, hemophilia, severe allergic reactions. |
| Not Known | Confusion, hallucinations, taste disturbances, hypotension, vasculitis, pancreatitis, hepatitis, severe skin reactions. |
When to Seek Immediate Medical Attention
Severe Allergic Reaction: Difficulty breathing, swelling of the face/lips/tongue/throat.
Signs of Bleeding: Unexplained or prolonged bleeding, blood in urine or stool, coughing up blood.
Signs of TTP: Fever, weakness, confusion, yellowing of skin or eyes.
Signs of Stroke: Sudden numbness or weakness, confusion, difficulty speaking, vision problems, severe headache.
How Should I Store This Medication?
Proper storage is essential for maintaining the stability, efficacy, and safety of Lowplat Plus Tablets.
Optimal Storage Conditions
Temperature Control: Store at room temperature (20°C to 25°C), away from direct light and heat.
Keep Out of Reach: Keep the medication out of reach of children and pets.
Protect from Moisture: Store in the original package to protect from moisture.
Check Expiry: Do not use the medication if the expiry date has passed.
Who Manufactures Lowplat Plus Tablet?
Lowplat Plus Tablet is manufactured by a reputable pharmaceutical company in Pakistan, known for producing high-quality medications for various medical conditions.
Commitment to Quality and Safety
DRAP Approval: Registered with the Drug Regulatory Authority of Pakistan (DRAP).
GMP Compliance: Manufactured in facilities that follow strict Good Manufacturing Practices.
Quality Assurance: Each batch undergoes rigorous quality testing to ensure purity, potency, and consistency.
Patient Safety: A commitment to providing safe, effective, and high-quality medications.
Frequently Asked Questions (FAQs)
1. What is Lowplat Plus Tablet used for?
Lowplat Plus Tablet is used for the prevention of atherothrombotic events (heart attacks, strokes, and cardiovascular death) in patients with acute coronary syndrome or a history of cardiovascular disease. It is a dual antiplatelet therapy containing clopidogrel and aspirin.
2. How does Lowplat Plus Tablet work?
Lowplat Plus contains two complementary antiplatelet agents: clopidogrel (which inhibits the P2Y12 receptor on platelets) and aspirin (which irreversibly inhibits COX-1). Together, they prevent platelets from sticking together and forming dangerous blood clots.
3. Can Lowplat Plus be taken with food?
Yes, Lowplat Plus tablets can be taken with or without food. It is recommended to take it at the same time each day for consistent treatment.
4. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your normal schedule. Do not double the dose.
5. What is the recommended dose of Lowplat Plus?
The recommended dose is one tablet (75mg clopidogrel / 75mg aspirin) once daily. In acute coronary syndrome, a loading dose may be given as directed by the physician.
6. Is Lowplat Plus safe for elderly patients?
Yes, Lowplat Plus can be safely used in elderly patients. No dose adjustment is required.
7. What are the common side effects?
Common side effects include bleeding (including gastrointestinal, intracranial, and nasal bleeding), bruising, diarrhea, abdominal pain, and dyspepsia.
8. Do I need a prescription for Lowplat Plus Tablet?
Yes, Lowplat Plus Tablet is a prescription medication and is available only with a prescription from a qualified healthcare professional.
9. How should I store Lowplat Plus?
Store at room temperature, away from direct light and heat. Keep out of reach of children. Do not use after the expiry date.
10. What should I do if I experience side effects?
If you experience mild side effects, inform your doctor at your next appointment. If you experience severe allergic reactions, unexplained bleeding, or signs of TTP, seek immediate medical attention.
