TERBISIL TABLET 250 MG 10S

Description

Terbisil Tablet 250 MG is a powerful oral antifungal medication specifically formulated to combat stubborn fungal infections, most commonly those affecting the toenails and fingernails. Its active ingredient, Terbinafine, works by systematically eliminating the fungal pathogens from within, promoting the growth of new, healthy tissue. This prescription medication is a cornerstone of dermatological treatment for individuals seeking a definitive solution to persistent fungal conditions.

This comprehensive guide to Terbisil Tablet 250 MG will provide you with detailed insights into:

• Its primary uses and powerful mechanism of action.

• Correct dosage and administration guidelines for optimal results.

• Important safety precautions and potential side effects to consider.

• The trusted manufacturing standards behind the product.

• A clear comparison with other antifungal treatment options.

What is Terbisil Tablet 250 MG and How Does it Work for Fungal Infections?

Terbisil Tablet 250 MG is an oral antifungal agent belonging to the allylamine class of drugs. It is a first-line treatment for onychomycosis, the medical term for fungal nail infections. Understanding how Terbisil works is key to appreciating its efficacy.

The Science Behind Terbisil’s Antifungal Action
The key to Terbisil’s success lies in its targeted mechanism. It specifically inhibits a fungal enzyme called squalene epoxidase. This disruption halts the biosynthesis of ergosterol, a critical component of the fungal cell membrane. Without adequate ergosterol, the cell membrane becomes permeable and dysfunctional, leading to the eventual death of the fungal cell. This fungicidal action (killing the fungus) is often more effective than fungistatic action (merely preventing growth), leading to higher cure rates and lower relapse.

Uses and Key Features of Terbisil Tablets

What are the primary medical uses of Terbisil 250mg?
Terbisil is prescribed for a range of dermatological fungal infections. Its primary uses include:

• Onychomycosis (Fungal Nail Infection): This is the most common indication. It treats infections of the toenails and fingernails caused by dermatophytes.

• Tinea Pedis (Athlete’s Foot): A fungal infection of the feet, often characterized by itching, scaling, and blisters.

• Tinea Cruris (Jock Itch): A fungal infection of the groin and inner thighs.

• Tinea Corporis (Ringworm of the Body): A fungal infection that appears as a circular rash on the skin of the body.

• Cutaneous Candidiasis: Infections of the skin caused by Candida yeast species.

Key Features and Patient Benefits of Choosing Terbisil

• High Cure Rates: Clinical studies consistently show high efficacy and mycological cure rates for onychomycosis.

• Fungicidal Action: It kills the fungus rather than just suppressing its growth, reducing the chance of recurrence.

• Oral Administration: Provides systemic treatment, reaching the infection site through the bloodstream and nail bed.

• Convenient Once-Daily Dosing: Simplifies the treatment regimen, improving patient adherence.

• Promotes Healthy Nail Regrowth: As the infection clears, it allows for the gradual growth of new, clear, healthy nail tissue.

Ingredients and Pharmacological Profile

What is the active ingredient in Terbisil 250mg?
The sole active pharmaceutical ingredient in each Terbisil tablet is Terbinafine Hydrochloride, equivalent to 250mg of Terbinafine.

Excipients and Inactive Components
The tablet also contains a blend of inactive ingredients, or excipients, which ensure the stability, bioavailability, and physical structure of the medication. These typically include:

• Microcrystalline Cellulose

• Povidone

• Colloidal Anhydrous Silica

• Sodium Starch Glycolate

• Magnesium Stearate

• Hypromellose

• Titanium Dioxide

Directions for Use and Administration

How should I take Terbisil 250mg tablets?
For the treatment to be effective, it is crucial to follow the prescribed directions meticulously.

• Oral Consumption: Swallow the tablet whole with a full glass of water. Do not crush or chew it.

• Timing: It can be taken with or without food. However, taking it at a consistent time each day helps maintain steady drug levels in your body.

• Duration: Complete the full course of treatment as prescribed by your doctor, even if your symptoms improve. Stopping early can lead to a relapse of the infection.

Dosage Information for Fungal Infections

What is the standard dosage of Terbisil for adults?

Dosage is determined by a healthcare professional based on the type and severity of the infection. The following are typical adult dosage guidelines:

Are there specific dosage instructions for elderly patients or those with liver/kidney issues?
Yes, dosage adjustments are critical for certain populations.

• Elderly Patients: No specific adjustment is usually needed, but careful monitoring is advised.

• Patients with Liver Impairment (Hepatic Disease): Terbisil is contraindicated in patients with active or chronic liver disease. Dose reduction or alternative therapy may be necessary for those with mild to moderate impairment.

• Patients with Kidney Impairment (Renal Disease): If creatinine clearance is less than 50 mL/min, a 50% dose reduction is recommended.

Precautions and Important Safety Warnings

What are the critical precautions before taking Terbisil?
Before starting treatment with Terbisil, a thorough medical evaluation is essential.

• Liver Function: Inform your doctor if you have a history of liver disease. Baseline liver function tests are often recommended before and during prolonged therapy.

• Pregnancy and Breastfeeding: Terbisil is not recommended during pregnancy. It is excreted in breast milk, so breastfeeding should be discontinued during therapy.

• Drug Interactions: Disclose all medications you are taking, especially Rifampin, Cimetidine, Terfenadine, Ciclosporin, and certain SSRIs like Sertraline.

• Allergies: Do not take this medicine if you are allergic to Terbinafine or any of its inactive ingredients.

• Pre-existing Conditions: Inform your doctor about any history of lupus, psoriasis, or kidney problems.

Potential Side Effects and Adverse Reactions

What are the common and serious side effects of Terbisil?
Like all medicines, Terbisil can cause side effects, although not everybody gets them.

Common Side Effects (Affecting up to 1 in 10 people)

• Headache

• Gastrointestinal disturbances (loss of appetite, indigestion, nausea, abdominal pain)

• Skin rash or itching

• Muscle and joint pain

• Taste disturbance or loss (usually reversible after treatment ends)

Serious Side Effects (Seek immediate medical attention)

• Signs of Liver Problems: Persistent nausea, vomiting, abdominal pain, dark urine, yellowing of the skin or eyes (jaundice), unusual tiredness.

• Severe Skin Reactions: Widespread skin rash, blistering, or peeling.

• Symptoms of Lupus Erythematosus: Unexplained persistent joint pain, skin lesions that worsen in the sun.

• Vision Changes.

• Serious Allergic Reaction (Anaphylaxis): Swelling of the face, tongue, or throat, severe dizziness, trouble breathing.

Storage Instructions for Product Integrity

How should I store my Terbisil tablets to maintain their potency?
Proper storage is vital for ensuring the medication remains safe and effective throughout its shelf life.

• Temperature: Store below 30°C, in a cool, dry place.

• Moisture: Keep the tablets in their original blister pack to protect them from light and moisture.

• Accessibility: Keep the container tightly closed and out of the sight and reach of children.

• Expiry: Do not use the tablets after the expiration date printed on the pack.

Manufacturer Information and Quality Assurance

Who manufactures Terbisil 250mg tablets?
Terbisil is manufactured by Sun Pharmaceutical Industries Ltd., a globally recognized, trusted pharmaceutical company based in India. Sun Pharma is renowned for its commitment to:

• Good Manufacturing Practices (GMP): Adherence to the highest international quality standards in every step of production.

• Research and Development: Continuous investment in pharmaceutical innovation.

• Global Reach: Providing high-quality, affordable medicines to patients worldwide.

Comprehensive Benefits of Terbisil Treatment

Why is Terbisil considered a superior choice for fungal nail cure?
Choosing Terbisil offers a multitude of benefits for patients suffering from stubborn fungal infections.

• Definitive Eradication: Its fungicidal action offers a complete cure, not just symptom management.

• High Success Rate: Proven in clinical trials to be highly effective against the most common causative fungi.

• Systemic Penetration: Reaches the site of infection through the nail matrix and bed, which topical treatments cannot effectively access.

• Long-Term Results: By eliminating the underlying infection, it promotes the sustained growth of healthy nails, preventing recurrence.

• Treatment Convenience: The once-daily oral regimen is far more convenient than daily application of topical solutions.

Comparison: Terbisil vs. Other Antifungal Treatments

How does Terbisil (Terbinafine) compare to other antifungal agents like Itraconazole?
Understanding the differences helps in making an informed treatment decision.

Frequently Asked Questions (FAQs)

How long does it take for Terbisil to show results for toenail fungus?
While you may not see immediate visual changes, Terbisil begins working systemically from the first dose. Visible improvement, where the new, healthy nail starts growing from the cuticle, typically becomes noticeable after 2-3 months of continuous treatment. It can take 9-12 months for a toenail to fully grow out.

Can I consume alcohol while taking Terbisil tablets?
It is strongly advised to avoid alcohol during your treatment with Terbisil. While direct interaction is not fully established, both Terbinafine and alcohol can affect the liver. Concurrent use increases the strain on the liver and the risk of hepatotoxicity.

What should I do if I miss a dose of my Terbisil tablet?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

Is a prescription required to purchase Terbisil 250mg?
Yes, Terbisil is a prescription-only medication (POM). You must consult a qualified healthcare professional, such as a dermatologist or general physician, who can diagnose your condition and determine if Terbisil is the appropriate and safe treatment for you.

Does Terbisil cause permanent taste loss?
Taste disturbance, including a complete loss of taste, is a known side effect. In the vast majority of reported cases, this effect is reversible, with taste perception returning to normal within several weeks after stopping the medication. However, in rare instances, the disturbance can be prolonged or permanent.