Description

TANZO INJECTION 4.5 GM is a powerful, broad-spectrum parenteral antibiotic combination used to combat a wide range of severe and moderate bacterial infections in hospitalized patients. This injectable medication is a critical tool for healthcare professionals treating complex infections, particularly those acquired in hospital settings. It is formulated to be effective against many resistant bacteria, making it a first-line defense in serious clinical situations.

This product is engineered for efficacy and reliability, offering a robust solution for systemic bacterial invasions.

✔️ Combats multi-drug resistant bacterial strains.
✔️ Used for intra-abdominal infections, pneumonia, and skin structure infections.
✔️ Formulated with a beta-lactamase inhibitor to enhance antibiotic potency.
✔️ Manufactured under strict Good Manufacturing Practices (GMP) for assured quality.

What is TANZO INJECTION 4.5 GM and what are its primary uses?

TANZO INJECTION is a sterile, parenteral preparation combining two active pharmaceutical ingredients: Piperacillin, a broad-spectrum penicillin antibiotic, and Tazobactam, a beta-lactamase inhibitor. This combination is specifically designed to treat severe systemic bacterial infections where other antibiotics may fail. Its primary clinical application is in a hospital environment for managing complicated infections affecting various organ systems.

Comprehensive List of Uses and Indications for this Antibiotic

TANZO INJECTION is prescribed by medical professionals for a variety of serious bacterial infections. The key indications include, but are not limited to:

• Complicated Intra-Abdominal Infections: Such as peritonitis and abscesses resulting from a ruptured appendix or other gastrointestinal perforations.

• Complicated Skin and Skin Structure Infections: Including deep wound infections, major abscesses, and infected ulcers, particularly those with tissue necrosis.

• Nosocomial Pneumonia: This refers to hospital-acquired pneumonia, including ventilator-associated pneumonia, which is often caused by resistant pathogens.

• Complicated Urinary Tract Infections (Pyelonephritis): Especially infections that have spread to the kidneys and are not responsive to oral antibiotics.

• Neutropenic Fever: Used empirically in patients with low white blood cell counts (neutropenia) who develop a fever, signaling a potential severe infection.

• Gynecological Infections: Such as postpartum endometritis and pelvic inflammatory disease (PID) of a severe nature.

• Septicemia and Bacteremia: For treating serious bloodstream infections that can lead to sepsis, a life-threatening condition.

What are the key features and benefits of using TANZO INJECTION 4.5 GM?

The therapeutic profile of TANZO INJECTION 4.5 GM is defined by several critical features that make it a preferred choice in hospital formularies.

• Broad-Spectrum Antibacterial Coverage: It is effective against a wide array of Gram-positive, Gram-negative, and anaerobic bacteria.

• Synergistic Action against Beta-Lactamase Producing Bacteria: The Tazobactam component inactivates the bacterial enzymes (beta-lactamases) that would otherwise destroy Piperacillin, thereby restoring and extending its antibiotic efficacy.

• High Clinical Success Rates: Extensive clinical trials and post-marketing surveillance have demonstrated high efficacy in eradicating pathogens and resolving infections.

• Parenteral Administration for Rapid Action: Intravenous (IV) infusion ensures the drug is delivered directly into the bloodstream, achieving high serum concentrations quickly, which is crucial in severe infections.

• Standardized and Predictable Dosing Regimen: The 4.5 gm strength is a standard dose, simplifying the preparation and administration process for healthcare staff.

What are the active ingredients in TANZO INJECTION 4.5 GM?

The therapeutic power of TANZO INJECTION 4.5 GM stems from its dual-component formulation. Each 4.5 gram vial contains a precise ratio of two active ingredients.

• Piperacillin (4.0 gm): This is an extended-spectrum ureidopenicillin antibiotic. It works by interfering with the synthesis of the bacterial cell wall. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, ultimately leading to cell lysis and death. This mechanism is highly effective against a broad range of bacteria during their growth and multiplication phase.

• Tazobactam (0.5 gm): This is not an antibiotic itself but a beta-lactamase inhibitor. Many bacteria develop resistance by producing enzymes called beta-lactamases, which break down penicillin-class antibiotics before they can act. Tazobactam irreversibly inhibits these enzymes, protecting Piperacillin from degradation and allowing it to effectively target and kill the resistant bacteria.

How should TANZO INJECTION 4.5 GM be administered correctly?

TANZO INJECTION is administered exclusively by healthcare professionals in a clinical setting. It is not for personal, at-home use. The administration process is critical for both safety and efficacy.

Step-by-Step Directions for Use and Reconstitution

1. Reconstitution: The powder in the vial must first be reconstituted with a suitable diluent, such as Sterile Water for Injection, 0.9% Sodium Chloride, or Dextrose Solution. The required volume is added to the vial and shaken vigorously until the powder is completely dissolved.

2. Further Dilution: The resulting solution is then withdrawn and must be further diluted into a larger volume (e.g., 50 mL to 150 mL) of a compatible IV fluid for infusion. Common bags contain 0.9% Sodium Chloride or 5% Dextrose.

3. Intravenous Infusion: The final diluted solution is administered to the patient slowly via an intravenous drip (infusion) over a period of 30 minutes. The infusion must be conducted using sterile equipment and techniques to prevent contamination.

4. Compatibility Check: The solution should be inspected visually for particulate matter or discoloration before administration. It should only be used if the solution is clear and free from visible particles.

What is the recommended dosage for TANZO INJECTION 4.5 GM?

The dosage of TANZO INJECTION is determined by a qualified physician based on the severity and location of the infection, the patient’s renal (kidney) function, and their overall health status.

Standard Adult Dosage Guidelines for Various Infections

For patients with normal kidney function, the typical dosage regimen is as follows:

Crucial Consideration: Renal Impairment Dosing
For patients with impaired kidney function (as measured by creatinine clearance), the dosing interval must be extended. A doctor will calculate the specific interval (e.g., every 12 hours or longer) based on the patient’s individual test results to prevent drug accumulation and potential toxicity.

What precautions should be taken before using TANZO INJECTION?

Safety is paramount when using potent injectable antibiotics. Several precautions are essential to minimize risks.

Important Warnings and Contraindications for Patients

• Hypersensitivity and Allergy: This product is contraindicated in patients with a known history of severe allergic reactions (e.g., anaphylaxis) to any penicillin, beta-lactam antibiotic, or other components of the formulation.

• Renal Function Monitoring: Dosage adjustment is imperative in patients with moderate to severe renal impairment to avoid seizures or other neurotoxic events.

• Pregnancy and Lactation: Use during pregnancy only if clearly needed. Piperacillin and Tazobactam are excreted in low concentrations in human milk; caution is advised when administering to a nursing woman.

• Blood Cell Counts: Prolonged use may result in overgrowth of non-susceptible organisms. Periodic assessment of organ system functions, including renal, hepatic, and hematopoietic (blood), is recommended during prolonged therapy.

• Sodium Content: Each 4.5 gm vial contains a significant amount of sodium (approximately 10 mEq or 230 mg), which must be considered for patients on a sodium-restricted diet.

• Drug Interactions: Inform your doctor about all other medications you are taking, as TANZO may interact with anticoagulants (like warfarin), methotrexate, and vecuronium, among others.

What are the potential side effects of TANZO INJECTION?

Like all potent medications, TANZO INJECTION can cause side effects, although not everybody gets them. It is crucial to be aware of these potential adverse reactions.

Common and Serious Adverse Reactions to Monitor

The most frequently reported side effects are generally mild and transient.

• Common Side Effects:

  • Local reactions at the injection site (e.g., inflammation, phlebitis, pain).

  • Diarrhea, nausea, vomiting, and constipation.

  • Headache, insomnia, and fever.

  • Skin rashes and pruritus (itching).

• Serious Side Effects (Require Immediate Medical Attention):

  • Signs of a severe allergic reaction: hives, difficulty breathing, swelling of the face or throat, rapid heart rate.

  • Severe skin reactions: Stevens-Johnson Syndrome, toxic epidermal necrolysis (blistering, peeling skin).

  • Watery or bloody diarrhea (a symptom of Clostridium difficile-associated diarrhea).

  • Unusual bleeding or bruising (indicating blood dyscrasias).

  • Seizures or significant neurological symptoms.

  • Signs of kidney problems: little or no urination.

How should I store TANZO INJECTION for optimal stability?

Proper storage is essential to maintain the sterility, potency, and safety of the product.

• Unreconstituted Vials: Store in a cool, dry place, protected from light. Do not freeze. The storage temperature should not exceed 25-30°C (room temperature).

• Reconstituted Solution: The reconstituted solution in the vial is stable for 24 hours at room temperature or for 7 days if refrigerated at 2-8°C.

• Diluted Solution for Infusion: The stability of the final diluted solution for IV infusion depends on the diluent used. When diluted with 0.9% Sodium Chloride, it is stable for 24 hours at room temperature or 7 days refrigerated. With Dextrose solutions, stability is limited to 24 hours at room temperature only. Do not freeze the diluted solutions.

Who is the manufacturer of TANZO INJECTION?

TANZO INJECTION is manufactured by leading pharmaceutical companies with a strong commitment to global healthcare standards. The product is typically produced by Mylan Pharmaceuticals or its affiliated entities, a company renowned for its high-quality generic medicines. The manufacturing facilities operate in full compliance with World Health Organization (WHO) Good Manufacturing Practices (GMP) and are subject to rigorous inspections by international regulatory bodies. This ensures that every vial meets stringent standards of purity, potency, and sterility.

What are the primary health benefits of using TANZO INJECTION?

The administration of TANZO INJECTION provides significant clinical advantages in the management of severe infections.

• Effective Against Resistant Pathogens: Its unique formulation overcomes a common mechanism of bacterial resistance, making it a powerful tool against many drug-resistant hospital-acquired infections.

• Rapid Onset of Therapeutic Action: Intravenous administration leads to quick achievement of high blood and tissue concentrations, which is critical for controlling rapidly progressing infections like sepsis.

• Comprehensive Anti-Bacterial Coverage: It provides a single-agent solution for polymicrobial infections (infections caused by multiple types of bacteria), which are common in abdominal and pelvic infections, potentially reducing the need for multiple antibiotics.

• Proven Efficacy in Critically Ill Patients: Its safety and efficacy profile is well-established in vulnerable patient populations, including those with neutropenia or in intensive care units.

• Standardized Dosing for Consistent Outcomes: The well-defined pharmacokinetic profile allows for predictable dosing, facilitating effective treatment planning by clinicians.

How does TANZO INJECTION compare to other antibiotics?

Patients and healthcare providers often need to understand how TANZO (Piperacillin/Tazobactam) stands against other common intravenous antibiotic options. The following table provides a comparative overview.

Frequently Asked Questions (FAQs) about TANZO INJECTION

Is TANZO INJECTION a penicillin drug?

Yes, TANZO INJECTION contains Piperacillin, which is a type of penicillin antibiotic. Therefore, patients with a known penicillin allergy should not receive this medication and must inform their doctor of this allergy.

Can TANZO INJECTION be used to treat a urinary tract infection?

Yes, TANZO INJECTION is an effective treatment for complicated urinary tract infections, including pyelonephritis (kidney infection), especially when caused by multi-drug resistant bacteria or when oral antibiotics have failed.

What is the duration of treatment with this injectable antibiotic?

The duration of therapy with TANZO INJECTION is determined by the severity and site of the infection and the patient’s clinical response. Treatment is typically continued for at least 7 to 14 days. For severe or deep-seated infections, a longer course may be necessary. The decision is always made by the treating physician.

How does the Tazobactam component work in this medication?

Tazobactam is a beta-lactamase inhibitor. Its primary role is to protect the Piperacillin component from being destroyed by beta-lactamase enzymes produced by resistant bacteria. This action “shields” the antibiotic, allowing it to effectively kill a wider range of bacteria than it could alone.

What should I do if I miss a scheduled dose of this antibiotic?

In a hospital setting, the medical staff manages the dosing schedule. If you are on outpatient IV antibiotic therapy and miss a dose, you should contact your healthcare provider or home health nurse immediately for instructions. Do not double the next dose to make up for the missed one.

Can this medication cause digestive issues like diarrhea?

Yes, diarrhea is a common side effect of many antibiotics, including TANZO INJECTION. In some cases, antibiotic use can lead to an overgrowth of a bacterium called C. difficile, causing severe, watery, or bloody diarrhea. If you experience this, contact your doctor right away.

Is it safe to use TANZO INJECTION during pregnancy?

TANZO INJECTION is classified as a Pregnancy Category B drug. This means animal reproduction studies have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as determined by a healthcare professional.