GRASIL INJECTION 500 MG 2 ML 1S

Description

Grasil Injection 500 mg is a trusted pharmaceutical solution specifically formulated for the prevention and management of nausea and vomiting. This medication is a cornerstone in supportive cancer care, helping patients manage the debilitating side effects of certain medical treatments. It is an essential tool for improving patient quality of life and treatment adherence during challenging therapeutic regimens.

This injectable formulation offers a reliable and fast-acting option for controlling emesis, ensuring that patients can continue their critical treatments with greater comfort and fewer interruptions.

• Targeted action against chemotherapy-induced and radiotherapy-induced nausea and vomiting.

• Proven efficacy in managing post-operative nausea and vomiting (PONO).

• High-quality formulation manufactured under strict Good Manufacturing Practices (GMP).

• Convenient pre-filled syringe format for accurate dosing and ease of administration.

What is Grasil Injection 500 mg and What Are Its Primary Uses?

Grasil Injection contains the active pharmaceutical ingredient Granisetron, which belongs to a class of drugs known as 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance in the body that can trigger nausea and vomiting. This makes it exceptionally effective in specific clinical scenarios where controlling emesis is critical.

What conditions is Grasil Injection 500 mg used for?

Grasil Injection is primarily indicated for the management and prevention of nausea and vomiting in the following situations:

• Chemotherapy-Induced Nausea and Vomiting (CINV): It is highly effective in preventing acute nausea and vomiting caused by highly emetogenic cancer chemotherapeutic agents.

• Radiotherapy-Induced Nausea and Vomiting (RINV): Used to control nausea and vomiting associated with radiation treatment, particularly total body irradiation or radiation targeting the abdomen.

• Postoperative Nausea and Vomiting (PONV): Administered to prevent and treat nausea and vomiting that can occur after surgical procedures, enhancing patient recovery.

Key Features and Benefits of Choosing Grasil Injection 500 mg

Why should healthcare providers and patients consider Grasil Injection? Its profile is built on a foundation of efficacy, safety, and quality.

• Rapid Onset of Action: As an injectable formulation, it provides a quick therapeutic effect, which is crucial for patients undergoing emetogenic treatments.

• High Efficacy Rate: Demonstrates a significant success rate in completely preventing nausea and vomiting episodes in a majority of patients.

• Long-Lasting Protection: Offers sustained control over emetic episodes, reducing the frequency of dosing.

• Well-Tolerated Profile: Generally associated with a lower incidence of certain side effects like extrapyramidal symptoms compared to some older antiemetic drugs.

• Manufacturing Quality: Produced in facilities that comply with WHO-GMP standards, ensuring every batch meets stringent quality and purity benchmarks.

Active Ingredient: Granisetron Hydrochloride

The sole active ingredient in Grasil Injection is Granisetron Hydrochloride, equivalent to 500mg of Granisetron per 2ml. This powerful selective antagonist is the key to its therapeutic success.

How does Granisetron work to stop nausea and vomiting?

Granisetron specifically blocks serotonin (5-HT3) receptors located in the brain and the gastrointestinal tract. During chemotherapy, radiation, or surgery, the body often releases large amounts of serotonin, which stimulates the vagus nerve and the vomiting center in the brain. By inhibiting the 5-HT3 receptors, Granisetron effectively interrupts this nauseating signal before it can trigger the vomiting reflex, providing profound relief.

How Should I Administer Grasil Injection?

Grasil Injection is for parenteral administration only and should be administered by a healthcare professional in a clinical setting. Self-administration is not recommended.

What is the correct method for using Grasil Injection?

The injection can be given intravenously or intramuscularly as directed by a physician.

• Intravenous (IV) Injection: This is the most common route. It is typically administered as a slow intravenous injection over a period of 30 seconds, either undiluted or diluted in a compatible IV fluid.

• Intramuscular (IM) Injection: It can also be administered via deep intramuscular injection into a large muscle mass.

The healthcare professional will determine the appropriate route, dose, and timing based on the clinical context and the patient’s specific needs.

What is the Standard Dosage for Grasil Injection 500mg?

Dosage is always determined by a qualified physician based on the indication, the patient’s condition, and the emetogenic potential of the triggering agent.

How is the dosage of Grasil Injection determined for chemotherapy patients?

For the prevention of chemotherapy-induced nausea and vomiting (CINV), a single dose of 500mg (one 2ml injection) is typically administered intravenously, diluted in 20-50ml of infusion fluid and given over 5 minutes. This dose is administered within an hour before the start of chemotherapy. The dosage may be adjusted for specific patient populations, such as those with hepatic impairment, under a doctor’s strict supervision.

Important Precautions and Safety Warnings

While Grasil Injection is highly effective, it is crucial to be aware of certain precautions to ensure its safe use.

Who should avoid using Grasil Injection?

• Hypersensitivity: Patients with a known allergy to Granisetron or any other components of the formulation should not use this medicine.

• Concomitant Use with Apomorphine: Concomitant use with Apomorphine is contraindicated due to the risk of profound hypotension and loss of consciousness.

What are the general precautions for using this antiemetic injection?

• Medical History: Inform your doctor if you have a history of heart conditions, such as congestive heart failure or arrhythmias, as Granisetron may affect electrical activity in the heart (QT prolongation).

• Electrolyte Imbalance: Patients with hypokalemia or hypomagnesemia should have these imbalances corrected before administration, as they can increase the risk of cardiac arrhythmias.

• Pregnancy and Lactation: The use of Grasil Injection during pregnancy or breastfeeding should only be considered if the potential benefit justifies the potential risk to the fetus or baby. Consult your physician.

• Subcutaneous Administration: The subcutaneous route of administration is not recommended.

What Are the Potential Side Effects of Grasil Injection?

Like all medicines, Grasil Injection can cause side effects, although not everybody gets them. Most side effects are mild to moderate and transient in nature.

Commonly reported adverse reactions may include:

• Headache

• Constipation

• Dizziness

• Weakness or fatigue

• Diarrhea or abdominal pain

Less common but more serious side effects require immediate medical attention:

• Signs of a severe allergic reaction (e.g., skin rash, itching, swelling of the face/tongue/throat, severe dizziness, trouble breathing).

• Symptoms of Serotonin Syndrome (e.g., agitation, hallucinations, fast heartbeat, high fever, muscle stiffness, nausea/vomiting/diarrhea).

• Changes in heart rhythm (e.g., fast/irregular heartbeat, severe dizziness, fainting).

How Should I Store Grasil Injection?

Proper storage is essential for maintaining the stability and efficacy of the medication.

What are the ideal storage conditions for this injectable medicine?

• Store in a cool, dry place, protected from light.

• The recommended storage temperature is below 25°C.

• Keep the injection in its outer carton until the time of use to protect it from light.

• Do not freeze the injection.

• Keep out of the reach and sight of children.

• Do not use the injection after the expiry date which is stated on the label and carton.

Manufacturer and Sourcing Information

Grasil Injection is manufactured by reputable pharmaceutical companies committed to global quality standards. The product is sourced from facilities that are certified for Good Manufacturing Practices (GMP), ensuring that every step of the manufacturing process, from raw material sourcing to final packaging, adheres to the highest levels of quality control and hygiene. This guarantees the product’s identity, strength, purity, and quality for every single unit supplied.

Comprehensive Health Benefits of Grasil Injection

The benefits of using Grasil Injection extend beyond simply controlling a symptom; they contribute significantly to the overall success of medical treatment.

• Enhances Quality of Life: By effectively preventing debilitating nausea and vomiting, it allows patients to maintain a better nutritional status, hydration, and overall well-being during taxing treatments like chemotherapy.

• Improves Treatment Adherence: The fear of nausea and vomiting is a major reason patients may delay or discontinue life-saving cancer therapy. Effective management with Grasil helps ensure patients complete their prescribed treatment cycles.

• Facilitates Smoother Recovery: In post-operative settings, preventing PONV leads to a more comfortable recovery, potentially shorter hospital stays, and a faster return to normal activities.

• Provides Predictable Control: Its reliable and long-lasting action gives both patients and healthcare providers confidence in managing a distressing side effect, reducing anxiety and emergency interventions.

How Does Grasil Injection Compare to Other Antiemetic Medications?

Choosing the right antiemetic often involves comparing options. Here’s how Grasil (Granisetron) stands against common alternatives.

Frequently Asked Questions About Grasil Injection 500mg

How quickly does Grasil Injection start working?
Grasil Injection begins working very quickly, often within a few minutes when administered intravenously, making it ideal for preventing acute nausea and vomiting.

Can Grasil Injection be given to children?
The use of Granisetron in pediatric patients is established, but the dose is based on body surface area or weight. A pediatrician or oncologist must determine the appropriate dosage and administration for a child.

What should I do if I miss a dose of Grasil?
Grasil is typically administered as a single dose before a specific event (like chemotherapy). It is not a scheduled daily medication. If you miss a scheduled pre-treatment dose, inform your healthcare team immediately.

Is it safe to take Grasil with other medications?
While Grasil has few known drug interactions, you must inform your doctor about all other medicines you are taking, including prescription, over-the-counter, and herbal products. Particular caution is advised with medications that can prolong the QT interval.

Can Grasil Injection cause constipation?
Yes, constipation is a commonly reported side effect of 5-HT3 receptor antagonists like Granisetron. Maintaining adequate hydration and dietary fiber intake can help. Consult your doctor if it becomes severe or bothersome.

How long do the effects of a single Grasil Injection last?
A single injection of Grasil 500mg can provide antiemetic protection for up to 24 hours, effectively covering the acute phase of CINV.