Description

Oxidil Injection IV 250 mg is a powerful prescription antibiotic medication formulated to combat a wide spectrum of serious bacterial infections. It belongs to the cephalosporin class of antibiotics, working effectively to eliminate bacteria that cause infections in various parts of the body. This intravenous solution is designed for clinical settings where rapid and potent therapeutic action is required under strict medical supervision.

This product is engineered for efficacy and reliability, offering a critical line of defense against pathogenic bacteria. Below is a summary of its core value propositions:

• Targets and eliminates a broad range of susceptible bacteria.

• Administered intravenously for fast absorption and immediate systemic action.

• Manufactured under stringent Good Manufacturing Practices (GMP) for assured quality and purity.

• Provides a potent therapeutic option for healthcare professionals treating complex infections.

What is Oxidil Injection IV 250 mg and What Are Its Primary Uses?

Oxidil Injection IV 250 mg is a sterile, parenteral antibiotic containing Cefuroxime sodium as its active pharmaceutical ingredient. As a second-generation cephalosporin, it is structurally similar to penicillin but developed to be effective against a wider range of bacteria and more resistant to bacterial enzymes. Its primary function is bactericidal, meaning it directly kills bacteria by interfering with the synthesis of their cell walls, leading to the destruction of the microorganisms.

What specific bacterial infections does Oxidil Injection IV 250 mg treat?

Oxidil Injection IV 250 mg is prescribed for moderate to severe bacterial infections caused by susceptible strains of microorganisms. Its clinical applications are extensive and cover multiple body systems.

• Lower Respiratory Tract Infections: Such as bacterial pneumonia, bronchitis, and lung abscesses.

• Urinary Tract Infections (UTIs): Including complicated pyelonephritis and cystitis.

• Skin and Skin Structure Infections: Like cellulitis, abscesses, and wound infections.

• Bone and Joint Infections: Including osteomyelitis and septic arthritis.

• Gynecological Infections: Such as pelvic inflammatory disease (PID) and endometritis.

• Meningitis: Bacterial infections of the membranes surrounding the brain and spinal cord.

• Gonorrhea: Specifically, uncomplicated gonococcal infections.

• Septicemia: Serious bloodstream infections, also known as bacteremia.

• Prophylactic Use: To prevent postoperative infections in certain surgical procedures.

Key Features and Therapeutic Benefits of Oxidil Injection IV 250 mg

Why Choose Oxidil Injection IV 250 mg for Antibacterial Therapy?

Oxidil Injection IV 250 mg stands out due to its robust pharmacological profile and patient-centric formulation. It is a trusted choice in hospital formularies and clinical practice for several compelling reasons.

What are the main advantages of using Oxidil Injection IV 250 mg?

• Broad-Spectrum Antibacterial Activity: It is effective against a wide array of Gram-positive and Gram-negative bacteria, making it a versatile tool for empiric therapy before specific bacterial culture results are available.

• Beta-Lactamase Stability: A significant benefit is its resistance to degradation by many beta-lactamase enzymes, which are produced by some bacteria to develop resistance to other antibiotics like penicillin and earlier cephalosporins.

• Rapid Onset of Action: Intravenous administration ensures the drug is delivered directly into the bloodstream, achieving high serum concentrations quickly for immediate therapeutic effect.

• High Purity and Sterility Assurance: The product is manufactured in state-of-the-art facilities complying with WHO-GMP standards, ensuring every vial is free from pyrogens and contaminants.

• Proven Clinical Efficacy: Backed by extensive clinical studies and decades of use in medical practice, establishing a strong record of success in treating diverse infections.

Active Pharmaceutical Ingredient: Cefuroxime Sodium

The sole active ingredient in Oxidil Injection IV 250 mg is Cefuroxime, presented as Cefuroxime Sodium. Each 250mg vial contains the equivalent of 250mg of Cefuroxime. This ingredient is the cornerstone of the product’s mechanism of action.

How does Cefuroxime work to fight infections?

Cefuroxime sodium is a bactericidal agent. It exerts its effect by binding to specific penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This binding activity inhibits the final transpeptidation step of peptidoglycan synthesis, a critical process for bacterial cell wall formation. As a result, the cell wall is weakened and becomes structurally unstable, leading to cell lysis (rupture) and death of the bacterium. This targeted mechanism makes it highly effective against growing and dividing bacteria.

How is Oxidil Injection Correctly Administered?

Directions for Use and Administration Protocol

Oxidil Injection is strictly for intravenous use and must be administered by a qualified healthcare professional in a controlled medical environment. Self-administration is not recommended and can be dangerous.

What is the proper method for intravenous injection?

The injection can be given as a slow IV bolus over 3 to 5 minutes or as an intermittent IV infusion over 30 minutes.

1. Reconstitution: The powder in the vial must be reconstituted with a suitable sterile diluent, such as Water for Injection. The exact volume will be specified in the package insert and depends on the desired concentration.

2. Mixing: Gently shake the vial until the powder is completely dissolved. Inspect the solution visually for particulate matter or discoloration before administration. The solution should be clear and free from visible particles.

3. Administration: The prepared solution is then drawn into a sterile syringe for IV bolus injection or added to an IV infusion bag.

4. Infusion: If administering via IV infusion, it is typically diluted in 50-100ml of a compatible IV fluid like Normal Saline (0.9% Sodium Chloride) or Dextrose Solution (5% Dextrose).

5. Monitoring: Patients should be monitored during and after administration for any signs of adverse reactions or hypersensitivity.

What is the Recommended Dosage of Oxidil Injection?

Dosage Information for Various Infections

The dosage of Oxidil Injection is not one-size-fits-all. It must be individualized based on the severity of the infection, the causative organism, and the patient’s overall renal function. The following table provides a general guideline, but the prescribing physician’s instructions are paramount.

How is dosage adjusted for patients with renal impairment?

For patients with impaired kidney function, the dosing interval must be extended. Since Cefuroxime is excreted by the kidneys, reduced function can lead to drug accumulation. The physician will determine the adjusted dosage schedule based on the patient’s creatinine clearance (CrCl) levels.

What Precautions Should Be Taken Before Using Oxidil?

Important Precautions and Contraindications

Patient safety is paramount. Certain conditions and patient histories necessitate caution before initiating therapy with Oxidil Injection.

Who should avoid or use Oxidil Injection with caution?

• Known Hypersensitivity: This product is contraindicated in patients with a known allergy to Cefuroxime, any other cephalosporin antibiotics, or any component of the formulation. Cross-sensitivity with penicillin antibiotics can occur in up to 10% of patients.

• Pregnancy and Lactation: While studies have not shown direct harm, it should be used during pregnancy only if clearly needed. Cefuroxime is excreted in human milk, so caution is advised when administering to a nursing mother.

• Gastrointestinal Conditions: Patients with a history of gastrointestinal disease, particularly colitis, should use this with caution as antibiotic use can cause pseudomembranous colitis.

• Renal Impairment: As noted, dosage adjustment is necessary for patients with significantly reduced renal function to prevent toxicity.

• Interference with Laboratory Tests: A false-positive reaction for glucose in the urine may occur with copper reduction tests (e.g., Benedict’s or Fehling’s solution). It does not affect enzyme-based tests.

What Are the Possible Side Effects of Oxidil Injection?

Potential Adverse Reactions and Side Effects

Like all potent medications, Oxidil Injection can cause side effects, though not everyone experiences them. It is crucial to be aware of potential adverse reactions.

What are the common and serious side effects to watch for?

• Common Side Effects: These are often mild and transient.

  • Gastrointestinal disturbances (nausea, vomiting, diarrhea).

  • Local reactions at the injection site (pain, phlebitis, inflammation).

  • Headache or dizziness.

  • Mild skin rashes or itching.

• Serious Side Effects: These require immediate medical attention.

  • Severe Allergic Reaction (Anaphylaxis): Symptoms include difficulty breathing, swelling of the face/tongue, rapid heart rate, and severe dizziness.

  • Severe Skin Reactions: Such as Stevens-Johnson syndrome, with symptoms like skin peeling, blistering, and a rash covering a large body area.

  • Watery or Bloody Diarrhea: This could be a sign of pseudomembranous colitis, a serious intestinal condition caused by C. difficile bacteria.

  • Signs of Liver Problems: Dark urine, persistent nausea, abdominal pain, or jaundice (yellowing of the skin or eyes).

  • Unusual bleeding or bruising.

How Should I Store Oxidil Injection Vials?

Storage Instructions for Stability and Potency

Proper storage is essential to maintain the drug’s sterility, potency, and safety profile.

• Unreconstituted Vials: Store in a cool, dry place, protected from light. The recommended storage temperature is below 25°C (77°F). Do not freeze the powder.

• Reconstituted Solution: The chemical and physical stability of the reconstituted solution has been established for a specific period. Once reconstituted, the solution should be used immediately. If storage is necessary, hold at 2°C to 8°C (36°F to 46°F) for no more than 24 hours.

• Further Diluted Infusions: Solutions diluted for IV infusion should be used as soon as possible. The stability period varies with the diluent used but typically ranges from 24 to 48 hours when stored refrigerated.

• Keep Out of Reach of Children: This is a prescription medicine and must be stored securely away from children and pets.

Who Manufactures Oxidil Injection?

Manufacturer Information and Quality Assurance

Oxidil Injection is manufactured by FDC Limited, a renowned and reputable pharmaceutical company based in India. FDC Ltd. has a long-standing history of producing high-quality, affordable medications and is a trusted name in both domestic and international markets.

What quality standards does the manufacturer adhere to?

The manufacturing processes for Oxidil Injection are carried out in facilities that are certified for compliance with WHO-GMP (World Health Organization – Good Manufacturing Practices) guidelines. This certification is a robust guarantee of quality, ensuring that every batch of the product is consistently produced and controlled according to the highest international standards of purity, safety, and efficacy. This involves rigorous quality control testing of raw materials, in-process checks, and final product assessment.

What Are the Overall Health Benefits of Using Oxidil?

Comprehensive Health Benefits and Clinical Outcomes

The administration of Oxidil Injection provides significant health benefits in the context of treating bacterial infections, contributing directly to patient recovery and public health.

• Effective Eradication of Pathogenic Bacteria: Directly targets and kills the bacteria responsible for the infection, resolving the underlying cause of illness.

• Prevention of Infection Spread: By controlling the primary infection site, it helps prevent the systemic spread of bacteria, which can lead to life-threatening conditions like sepsis.

• Reduction in Hospital Stay Duration: Effective and rapid treatment of infections can lead to quicker recovery, allowing for shorter hospitalizations and reducing healthcare costs.

• Management of Resistant Infections: Its stability against many beta-lactamase enzymes makes it a crucial option for treating infections that are resistant to ampicillin and amoxicillin.

• Prophylaxis in Surgical Settings: Its use before surgery significantly reduces the risk of postoperative surgical site infections, leading to better patient outcomes and reduced complication rates.

How Does Oxidil Compare to Other Antibiotics?

Comparison Table: Oxidil (Cefuroxime) vs. Key Alternatives

This table provides a comparative overview to help understand Oxidil’s position relative to other common antibiotic classes.

Frequently Asked Questions About Oxidil Injection

Answering Common Queries on Oxidil IV 250mg

Can Oxidil Injection be used for a tooth infection?
Yes, Oxidil Injection can be prescribed for severe dental abscesses or orofacial infections where the causative bacteria are susceptible to Cefuroxime. It is typically reserved for cases that have not responded to oral antibiotics or are severe enough to require hospitalization and IV therapy.

How quickly does Oxidil IV start working?
As an intravenous medication, Oxidil begins working almost immediately after infusion, as it reaches high concentrations in the bloodstream within minutes. Patients may start feeling symptom relief within 24 to 48 hours, but it is crucial to complete the full course of therapy as prescribed, even if you feel better.

What should I do if I miss a scheduled dose?
In a hospital setting, the medical staff will manage the dosing schedule. If you are on outpatient IV therapy and miss a dose, you should contact your healthcare provider immediately for instructions. Do not double the next dose to make up for the missed one.

Can I consume alcohol while on this medication?
It is generally advised to avoid alcohol during and for at least 48 hours after completing a course of antibiotics. While Cefuroxime does not have a classic disulfiram-like reaction (severe nausea and vomiting) as seen with some other antibiotics, alcohol can weaken the immune system and worsen side effects like dizziness or gastrointestinal upset, impairing recovery.

Is Oxidil a penicillin drug?
No, Oxidil (Cefuroxime) is not a penicillin. It is a cephalosporin antibiotic. However, because their chemical structures are similar, there is a risk of cross-allergenicity. If you have a known penicillin allergy, you must inform your doctor before receiving Oxidil Injection.