No-Spa IM/IV Inj 40mg 5Ampx2ml Tray

Description

No-Spa IM/IV Inj 40mg is a potent pharmaceutical formulation designed for the rapid relief of severe smooth muscle spasms. This injectable solution contains Drotaverine hydrochloride, a trusted antispasmodic agent that works directly to relax hyperactive muscles in various organ systems. It is a critical medication for managing acute painful conditions in clinical and emergency settings, offering targeted action when swift intervention is required. Below is a summary of its core attributes presented for quick comprehension.

✔ Contains 40mg of pure Drotaverine HCl per 2ml ampoule.
✔ Administered via intramuscular (IM) or intravenous (IV) routes for rapid onset.
✔ Specifically formulated for acute, severe spastic conditions.
✔ Targets spasms in gastrointestinal, biliary, urinary, and reproductive tracts.
✔ Manufactured under strict Good Manufacturing Practice (GMP) standards.
✔ Packaged in a secure, ready-to-use tray of 5 ampoules.

What is No-Spa IM/IV Inj 40mg and How Does It Work?

No-Spa IM/IV Inj 40mg is a direct-acting antispasmodic medication classified as a phosphodiesterase type 4 (PDE4) inhibitor. The primary pharmacological agent, Drotaverine hydrochloride, functions by selectively inhibiting the PDE4 enzyme. This inhibition leads to an increase in intracellular cyclic adenosine monophosphate (cAMP). Elevated cAMP levels cause relaxation of the smooth muscle fibers without affecting the autonomic nervous system. This mechanism is distinct from anticholinergic drugs, meaning it typically avoids side effects like dry mouth or blurred vision. The injectable form ensures bio-availability is achieved swiftly, making it an authoritative choice for hospital use, emergency rooms, and clinical procedures where oral administration is not feasible or fast enough.

What Are the Primary Uses and Key Features of This Antispasmodic Injection?

This section details the therapeutic applications and defining characteristics of No-Spa IM/IV 40mg, addressing both informational and commercial search intents.

Medical Uses and Indications for Drotaverine Injection:

• Acute Abdominal Pain Management: Used for rapid relief of spasms in conditions like biliary colic (gallbladder pain), renal colic (kidney stone pain), and intestinal colic.

• Gastrointestinal Disorders: Alleviates spasms associated with irritable bowel syndrome (IBS), gastritis, and enteritis during acute flare-ups.

• Urological Applications: Effectively reduces painful spasms of the ureter and bladder, aiding in conditions like ureterolithiasis and cystitis.

• Gynecological and Obstetric Care: Provides relief from dysmenorrhea (painful menstrual cramps) and is used in certain stages of childbirth to facilitate cervical dilation.

• Vascular Spasms: Can be employed as adjunct therapy for spasms in peripheral blood vessels.

• Diagnostic Aid: Used prior to certain radiographic or endoscopic procedures to reduce spastic interference.

Salient Features and Benefits:

• Rapid Onset of Action: Parenteral administration leads to quicker symptom relief compared to tablet forms, crucial for acute pain crises.

• Selective Action: Directly relaxes smooth muscles without significant impact on cardiovascular parameters at therapeutic doses.

• High Purity Formulation: Each ampoule contains a precise, sterile dose of the active pharmaceutical ingredient (API).

• Proven Efficacy: Backed by extensive clinical use and pharmacopoeial standards in many countries.

• Dual Administration Routes: Offers flexibility for healthcare professionals to choose between IM or IV injection based on patient needs and urgency.

• Convenient Packaging: The tray of 5 ampoules ensures a ready supply for short-term treatment cycles or multiple doses.

What is the Active Ingredient in No-Spa IM/IV Inj 40mg?

The No-Spa IM/IV Inj 40mg active ingredient in this formulation is Drotaverine Hydrochloride, present at a strength of 40mg per 2ml solution.

Detailed Ingredient Analysis:

• Drotaverine Hydrochloride (40mg): This is a benzylisoquinoline derivative known for its potent papaverine-like spasmolytic effects. It is a selective PDE4 inhibitor. The key benefit lies in its direct action on smooth muscle tissue, leading to:

  • Effective Spasmolysis: Rapid reduction of involuntary muscle contractions causing pain.

  • Improved Blood Flow: Vasodilation in spastic vessels enhances oxygenation to tissues.

  • Minimal Anticholinergic Effects: Unlike some antispasmodics, it generally does not block acetylcholine receptors, reducing common side effects.

• Excipients: The injectable solution also contains purified water and may contain pH adjusters and stabilizers to ensure sterility, stability, and tolerability. The exact composition of inactive ingredients is proprietary to the manufacturer but complies with injectable safety standards.

How Do You Administer No-Spa Injections Correctly?

Proper administration is critical for safety and efficacy. This information is for educational purposes; administration must be performed by a qualified healthcare professional.

Directions for Use for Healthcare Providers:

1. Aseptic Technique: Perform hand hygiene and prepare the injection site with an antiseptic swab.

2. Ampoule Opening: Snap open the glass ampoule at the marked point carefully.

3. Solution Withdrawal: Draw the clear, colorless solution into an appropriate sterile syringe using a filter needle if recommended.

4. Administration Route:

   • Intramuscular (IM) Injection: Typically administered deep into a large muscle mass (e.g., gluteus maximus or deltoid). This route provides a rapid but slightly slower onset than IV.

   • Intravenous (IV) Injection: Can be administered as a slow direct IV push over at least one minute or diluted in an infusion solution as per protocol. This offers the fastest relief.

5. Post-Injection: Apply gentle pressure and dispose of all sharps in a designated container.

Crucial Administration Guidelines:

• Inspect the solution visually for particulate matter or discoloration before use. Discard if present.

• Do not mix with other medications in the same syringe unless compatibility is known.

• The injection is for single-use only. Discard any unused solution from an opened ampoule.

What is the Standard Dosage Information for Drotaverine Injections?

Dosage is always determined by a physician based on diagnosis, severity, and patient response.

Recommended Dosage Overview:

• Adults: The usual dose is 40mg to 80mg (1 to 2 ampoules) per administration.

• Frequency: May be administered 1 to 3 times per day, as required. The maximum daily dose should not exceed 240mg (6 ampoules) in 24 hours.

• Elderly & Hepatic/Renal Impairment: Dose adjustment may be necessary; lower doses are often initiated.

• Children: Safety and efficacy in children are not fully established; use is strictly under medical supervision.

Dosage for Specific Conditions:

• For Acute Biliary or Renal Colic: 40-80mg injected intravenously for rapid decompression of spasmodic pain.

• For Cervical Dilation in Labour: A specific protocol of 40mg IM/IV, often repeated, as directed by an obstetrician.

• As a Diagnostic Aid: 40mg administered IM/IV 20-30 minutes prior to the procedure.

What Precautions and Warnings Are Associated with This Medication?

Understanding contraindications and safety measures is paramount for risk mitigation.

Contraindications (When NOT to Use):

• Patients with known hypersensitivity to Drotaverine or any excipient.

• Patients with severe hepatic (liver) impairment or severe renal (kidney) failure.

• Patients with cardiogenic shock, severe heart failure (low ejection fraction), or significant atrioventricular block.

• Conditions where antispasmodics might be harmful (e.g., paralytic ileus).

Important Precautions and Warnings:

• Pregnancy and Lactation: Use during pregnancy (especially the first trimester) and breastfeeding should be avoided unless absolutely necessary and prescribed by a doctor who has weighed the benefits against risks.

• Hypotension Risk: IV administration can cause a transient drop in blood pressure. Administer slowly, especially to hypotensive individuals.

• Driving and Operating Machinery: While less sedating than some alternatives, individuals may experience dizziness or lightheadedness; caution is advised.

• Underlying Cardiac Conditions: Use with caution in patients with existing heart rhythm disorders.

• Glaucoma: Although not anticholinergic, medical supervision is advised.

• Benign Prostatic Hyperplasia (BPH): Not a primary contraindication, but monitoring is suggested.

What Are the Possible Side Effects of No-Spa IM/IV Injection?

Most patients tolerate Drotaverine well, but like all medicines, it can have side effects.

Common and Less Serious Side Effects:

• Cardiovascular: Transient palpitations, feeling of heat, hypotension with rapid IV injection.

• Neurological: Headache, dizziness, vertigo.

• Gastrointestinal: Nausea, constipation.

• Local Reactions: Discomfort, burning, or hematoma at the injection site.

Rare but Serious Adverse Reactions:

• Allergic Reactions: Skin rash, itching (pruritus), urticaria (hives), and in rare cases, anaphylaxis.

• Cardiac Arrhythmias: Tachycardia (fast heart rate) or other rhythm disturbances.

• Central Nervous System: Insomnia, agitation.

• Hepatic: Isolated reports of elevated liver enzymes.

When to Seek Immediate Medical Attention: If signs of a severe allergic reaction (difficulty breathing, swelling of face/lips/tongue) or a significant cardiac event (severe chest pain, profound dizziness) occur.

How Should I Store This Injectable Medication?

Proper storage ensures stability and safety of the pharmaceutical product.

Optimal Storage Instructions:

• Store in the original packaging (tray) to protect from light.

• Keep at a controlled room temperature, typically between 15°C and 25°C (59°F – 77°F). Do not freeze.

• Keep out of reach and sight of children and pets.

• Do not use the injection if the solution is cloudy, discolored, or contains visible particles.

• Do not use after the expiration date printed on the ampoule and packaging.

Who Manufactures No-Spa 40mg IM/IV Injection?

Manufacturer Information: No-Spa is a well-established brand originally developed and popularized by the Hungarian pharmaceutical company Chinoin, now part of the Sanofi portfolio. The product available globally is often manufactured by licensed pharmaceutical companies under strict adherence to the original formula. These manufacturing partners operate state-of-the-art facilities certified for Good Manufacturing Practices (GMP) as per WHO, FDA, or EMA guidelines. This ensures batch-to-batch consistency, sterility assurance, and the highest quality control standards from raw material sourcing (API verification) to final packaging. The authority of the product stems from its long clinical history and compliance with international pharmacopoeias.

What Are the Comprehensive Benefits of Using This Antispasmodic Injection?

This section provides a deeper analysis of the therapeutic advantages, fulfilling commercial and transactional user intent.

Clinical and Patient-Centric Benefits:

• Targeted Pain Relief: Directly addresses the root cause of visceral pain—smooth muscle spasm—providing more specific relief than general analgesics.

• Facilitates Medical Procedures: By relaxing spasmodic muscles, it can improve the success and comfort of procedures like ERCP or hysteroscopy.

• Avoids Narcotic Dependence: Offers a potent alternative for managing acute colic pain, potentially reducing the need for opioid analgesics and associated risks.

• Therapeutic Versatility: A single agent useful across multiple medical specialties: gastroenterology, urology, gynecology, and vascular medicine.

• Established Safety Profile: Decades of clinical use have resulted in a well-understood side effect profile, allowing for confident administration under medical supervision.

• Cost-Effective Intervention: By quickly resolving acute episodes, it may reduce overall hospital stay duration and the need for more invasive interventions.

How Does Drotaverine Injection Compare to Other Antispasmodics?

The following comparison table highlights key differences, aiding in medical decision-making.

Comparison: No-Spa (Drotaverine) Injection vs. Key Alternatives

Frequently Asked Questions (FAQs) About No-Spa Injections

This section anticipates and answers real customer queries using semantic phrases for voice search and LLM optimization.

How fast does a No-Spa shot work for stomach pain?
Intravenous administration can provide onset of action within 2 to 5 minutes, offering swift relief from acute abdominal cramps and spasms. Intramuscular injection typically works within 15 to 30 minutes.

Can Drotaverine injection be used for period cramps?
Yes, it is a clinically recognized treatment for severe primary dysmenorrhea. The injection form is used for acute, debilitating menstrual pain under medical supervision, often providing faster relief than oral medications.

What is the difference between No-Spa tablets and No-Spa injections?
The active ingredient is the same. The injection delivers the drug directly into the bloodstream for immediate effect, making it suitable for severe, acute spasms. Tablets are for milder, chronic conditions and take longer to work as they must be absorbed through the gut.

Is Drotaverine safe for patients with high blood pressure?
It can be used with caution. While it may cause transient hypotension, it does not typically raise blood pressure. However, patients with uncontrolled hypertension or on antihypertensive drugs should be monitored, as interactions are possible. Always disclose your full medical history.

Can this injection be given during a gallbladder attack?
Yes, No-Spa injection is a first-line pharmacological agent for managing the intense pain of biliary colic during a gallbladder attack. It helps relax the spasming bile ducts.

Does No-Spa injection make you sleepy?
Drowsiness is not a commonly reported side effect. Some patients may experience dizziness or lightheadedness, especially with rapid IV push, which could impair alertness. It is less sedating than anticholinergic antispasmodics.

How many times can I take the No-Spa injection in a day?
The maximum recommended adult dose is typically 240mg of Drotaverine in 24 hours, which equates to 6 ampoules of the 40mg strength. Dosing frequency (1-3 times daily) must be strictly prescribed by a physician based on your specific condition.

What should I do if I miss a scheduled dose of the injection?
As this is an injectable administered in a clinical setting, missed doses are unlikely. If you are on a scheduled regimen and miss a dose, contact your healthcare provider for advice. Do not double the next dose.