Description
Lowplat Tablets 75mg (1 Box = 1 Strip) (1 Strip = 10 Tablets)
Product Overview
Lowplat 75mg Tablet is a prescription oral medication containing the active ingredient Clopidogrel. Manufactured by PharmEvo in Pakistan, this potent antiplatelet agent is specifically designed for the prevention of atherothrombotic events in patients with a history of cardiovascular disease. Lowplat works by irreversibly inhibiting the P2Y12 receptor on platelets, preventing them from sticking together and forming dangerous blood clots. Administered as a simple, once-daily oral tablet, Lowplat offers a convenient and effective treatment option for reducing the risk of heart attacks, strokes, and cardiovascular death. Each box contains 1 strip of 10 tablets (75mg each) .
This advanced antiplatelet therapy delivers effective cardiovascular protection:
Secondary Prevention of Cardiovascular Events: Indicated for the prevention of atherothrombotic events in patients with a history of myocardial infarction (heart attack), stroke, or established peripheral arterial disease.
Acute Coronary Syndrome (ACS) Management: Used in combination with aspirin for the management of acute coronary syndrome (unstable angina, non-ST-segment elevation MI, or ST-segment elevation MI) to reduce the rate of cardiovascular death, MI, and stroke.
Platelet Aggregation Inhibition: As a P2Y12 receptor antagonist, it irreversibly inhibits platelet activation and aggregation.
Once-Daily Dosing: Simple, once-daily oral administration for convenient and consistent treatment.
Prescription Medication: Requires a prescription from a qualified healthcare professional.
What are the Primary Uses and Key Features of Lowplat Tablet?
Lowplat Tablet serves as a specialized therapeutic solution for preventing atherothrombotic events in patients with established cardiovascular disease. It is designed to effectively reduce the risk of life-threatening blood clots.
Core Uses of This Medication
Secondary Prevention: Indicated for the secondary prevention of atherothrombotic events in patients with a history of myocardial infarction (heart attack), stroke, or established peripheral arterial disease (PAD). It reduces the combined endpoint of new ischemic stroke, new MI, and other vascular death.
Acute Coronary Syndrome (ACS) Management: Used in combination with aspirin for the management of acute coronary syndrome, including unstable angina, non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI), to reduce the rate of cardiovascular death, MI, and stroke.
Recent Myocardial Infarction: For patients who have had a recent heart attack, to reduce the risk of subsequent cardiovascular events.
Recent Stroke: For patients who have had a recent stroke, to reduce the risk of subsequent cardiovascular events.
Established Peripheral Arterial Disease: For patients with established PAD, to reduce the risk of cardiovascular events.
Standout Product Features
| Feature | Description |
|---|---|
| Active Ingredient: Clopidogrel | A potent P2Y12 receptor antagonist that inhibits platelet aggregation. |
| Strength: 75mg | Each tablet contains 75mg of clopidogrel (as clopidogrel bisulfate). |
| Manufacturer: PharmEvo | Manufactured by a reputable Pakistani pharmaceutical company. |
| Oral Administration | Convenient once-daily tablet that can be taken with or without food. |
| Proven Efficacy | Reduces the risk of cardiovascular death, MI, and stroke in high-risk patients. |
| Prescription Required | Available only with a prescription from a qualified healthcare professional. |
| Blister Packaging | Each box contains 1 strip of 10 tablets. |
What Key Ingredients are in Lowplat Tablet and How Does It Work?
Composition
| Component | Description |
|---|---|
| Clopidogrel | Each tablet contains 75mg of clopidogrel (as clopidogrel bisulfate). |
| Other Ingredients | Contains pharmaceutical excipients including tablet binders and coating agents. |
Mechanism of Action
Clopidogrel is a prodrug, one of whose metabolites is an inhibitor of platelet aggregation. It selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible, and the effect lasts for the lifespan of the platelet (approximately 7-10 days). By preventing platelets from sticking together, clopidogrel reduces the formation of blood clots that can block arteries and cause heart attacks or strokes.
Key Benefits
Reduces the risk of heart attacks, strokes, and cardiovascular death.
Prevents dangerous blood clots from forming in arteries.
Convenient once-daily oral administration.
Proven efficacy in high-risk cardiovascular patients.
Can be taken with or without food.
How Should I Use Lowplat Tablet Correctly?
Lowplat Tablet must be taken orally as prescribed by a healthcare professional. Do not self-adjust the dose.
Dosage and Administration
| Parameter | Details |
|---|---|
| Recommended Dose (Secondary Prevention) | 75 mg once daily. |
| Recommended Dose (ACS) | 300 mg loading dose, followed by 75 mg once daily. |
| STEMI Patients | 75 mg once daily, with or without a 300 mg loading dose. |
| Elderly Patients | No dose adjustment required. |
| Renal Impairment | No dose adjustment required. |
| Hepatic Impairment | Use with caution in patients with severe hepatic impairment. |
| Method of Administration | Take orally with water, with or without food. |
| Duration | Chronic therapy is typical, as prescribed by the physician. |
Method of Administration
Oral: Take the tablet orally with a glass of water.
With or Without Food: Can be taken with or without food.
Consistency: Take at the same time each day for consistent treatment.
Swallow Whole: Swallow the tablet whole; do not crush or chew.
Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Important Considerations
Prescription Only: This medication is available only with a prescription.
Pregnancy and Lactation: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.
Bleeding Risk: Inform your doctor if you have a history of bleeding disorders or conditions that increase bleeding risk.
Surgery: Inform your doctor if you are scheduled for any surgery or dental procedure, as you may need to stop taking Lowplat temporarily.
Monitoring: Regular monitoring may be required to assess bleeding risk and treatment response.
What Precautions Should I Be Aware of Before Taking This Medication?
While generally safe and well-tolerated, specific conditions and interactions require awareness and caution.
Key Warnings and Contraindications
Hypersensitivity: Contraindicated in patients with known hypersensitivity to clopidogrel or any excipients.
Active Bleeding: Contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Severe Hepatic Impairment: Contraindicated in patients with severe hepatic impairment.
Bleeding Risk: Clopidogrel increases the risk of bleeding, including gastrointestinal bleeding, intracranial hemorrhage, and bleeding from minor trauma.
CYP2C19 Poor Metabolizers: Patients who are poor metabolizers of CYP2C19 may have reduced effectiveness of clopidogrel and may require alternative therapy.
Thrombotic Thrombocytopenic Purpura (TTP): Rarely, clopidogrel can cause TTP, a serious condition that requires immediate medical attention.
Recent Major Surgery: Use with caution in patients with recent major surgery or trauma.
Alcohol: Alcohol consumption should be limited as it may increase the risk of gastrointestinal bleeding.
Drug Interactions
| Interaction | Recommendation |
|---|---|
| Aspirin | May increase bleeding risk; used together in ACS management under medical supervision. |
| Warfarin | Increased risk of bleeding; avoid concurrent use unless absolutely necessary. |
| NSAIDs | Increased risk of gastrointestinal bleeding; use with caution. |
| Omeprazole/Esomeprazole | May reduce the effectiveness of clopidogrel; consider using other acid-reducing agents. |
| CYP2C19 Inhibitors | May reduce the effectiveness of clopidogrel; monitor clinical response. |
When to Seek Immediate Medical Attention
Severe Allergic Reaction: Difficulty breathing, swelling of the face/lips/tongue/throat.
Signs of Bleeding: Unexplained or prolonged bleeding, blood in urine or stool, coughing up blood, vomiting blood.
Signs of TTP: Fever, weakness, confusion, yellowing of skin or eyes, dark urine.
Signs of Intracranial Hemorrhage: Severe headache, weakness on one side of the body, confusion, difficulty speaking.
Signs of Stroke: Sudden numbness or weakness, confusion, difficulty speaking or understanding speech, vision problems, severe headache.
Are There Any Potential Side Effects of Lowplat Tablet?
As with all medications, Lowplat Tablet may cause side effects, although not everyone experiences them.
Side Effects by Frequency
| Frequency | Side Effects |
|---|---|
| Common (≥1% to <10%) | Bleeding (including gastrointestinal, intracranial, and nasal bleeding), bruising, diarrhea, abdominal pain, dyspepsia. |
| Uncommon (≥0.1% to <1%) | Headache, dizziness, nausea, vomiting, skin rash, itching, thrombocytopenia, leukopenia, eosinophilia. |
| Rare (<0.1%) | Thrombotic thrombocytopenic purpura (TTP), aplastic anemia, severe thrombocytopenia, hemophilia, severe allergic reactions. |
| Not Known | Confusion, hallucinations, taste disturbances, hypotension, vasculitis, pancreatitis, hepatitis, severe skin reactions. |
When to Seek Immediate Medical Attention
Severe Allergic Reaction: Difficulty breathing, swelling of the face/lips/tongue/throat.
Signs of Bleeding: Unexplained or prolonged bleeding, blood in urine or stool, coughing up blood.
Signs of TTP: Fever, weakness, confusion, yellowing of skin or eyes.
Signs of Stroke: Sudden numbness or weakness, confusion, difficulty speaking, vision problems, severe headache.
How Should I Store This Medication?
Proper storage is essential for maintaining the stability, efficacy, and safety of Lowplat Tablets.
Optimal Storage Conditions
Temperature Control: Store at room temperature (20°C to 25°C), away from direct light and heat.
Keep Out of Reach: Keep the medication out of reach of children and pets.
Protect from Moisture: Store in the original package to protect from moisture.
Check Expiry: Do not use the medication if the expiry date has passed.
Who Manufactures Lowplat Tablet?
Lowplat Tablet is manufactured by PharmEvo in Pakistan, a reputable and well-established pharmaceutical company known for producing high-quality medications for various medical conditions.
Commitment to Quality and Safety
DRAP Approval: Registered with the Drug Regulatory Authority of Pakistan (DRAP).
GMP Compliance: Manufactured in facilities that follow strict Good Manufacturing Practices.
Quality Assurance: Each batch undergoes rigorous quality testing to ensure purity, potency, and consistency.
Patient Safety: A commitment to providing safe, effective, and high-quality medications.
Frequently Asked Questions (FAQs)
1. What is Lowplat Tablet used for?
Lowplat Tablet is used for the prevention of atherothrombotic events (heart attacks, strokes, and cardiovascular death) in patients with a history of cardiovascular disease, including recent myocardial infarction, recent stroke, or established peripheral arterial disease. It is also used in combination with aspirin for the management of acute coronary syndrome.
2. How does Lowplat Tablet work?
Lowplat contains clopidogrel, which irreversibly inhibits the P2Y12 receptor on platelets, preventing them from sticking together and forming dangerous blood clots.
3. Can Lowplat be taken with food?
Yes, Lowplat tablets can be taken with or without food. It is recommended to take it at the same time each day for consistent treatment.
4. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your normal schedule. Do not double the dose.
5. What is the recommended dose of Lowplat?
For secondary prevention, the recommended dose is 75 mg once daily. For acute coronary syndrome, a 300 mg loading dose is followed by 75 mg once daily, as prescribed by the physician.
6. Is Lowplat safe for elderly patients?
Yes, Lowplat can be safely used in elderly patients. No dose adjustment is required.
7. What are the common side effects?
Common side effects include bleeding (including gastrointestinal, intracranial, and nasal bleeding), bruising, diarrhea, abdominal pain, and dyspepsia.
8. Do I need a prescription for Lowplat Tablet?
Yes, Lowplat Tablet is a prescription medication and is available only with a prescription from a qualified healthcare professional.
9. How should I store Lowplat?
Store at room temperature, away from direct light and heat. Keep out of reach of children. Do not use after the expiry date.
10. What should I do if I experience side effects?
If you experience mild side effects, inform your doctor at your next appointment. If you experience severe allergic reactions, unexplained bleeding, or signs of TTP, seek immediate medical attention.
