Cart is emptyBRCAPRO Risk Calculator
Assess your genetic risk for BRCA1 and BRCA2 mutations
Demographics
Medical History
Cancer History
Risk Assessment Results
Probability of BRCA1/BRCA2 Mutation
Interpretation
Your calculated risk of having a BRCA1 or BRCA2 mutation is 27.6%, which falls into the moderate risk category.
BRCA mutations significantly increase lifetime risk for breast cancer (up to 72%) and ovarian cancer (up to 44%). This risk assessment is based on the BRCAPRO model that considers your personal and family cancer history.
Personalized Recommendations
- Genetic Counseling: Consider consultation with a certified genetic counselor to discuss testing options.
- Enhanced Screening: Begin annual breast MRI starting at age 25, and mammograms starting at age 30.
- Risk-Reducing Strategies: Discuss chemoprevention and risk-reducing surgeries with your healthcare provider.
- Family Testing: Encourage first-degree relatives to undergo genetic risk assessment.
- Lifestyle Modifications: Maintain healthy weight, limit alcohol, and exercise regularly.
Try More Free Tools:
- Try our Gail Score Chart – Gail Model Breast Cancer
- Try our Neuroblastoma Stage 4 Cancer (Symptoms & Survival Rate Tool)
- Try our Cancer Survival Rate Calculator (By Type & Age)
Table Of Contents
Free BRCAPRO Risk Assessment: Estimate Your Hereditary Cancer Probability
Hereditary cancer syndromes impact millions globally. Our clinically validated BRCAPRO calculator helps you estimate BRCA gene mutation probability – a key indicator for breast, ovarian, and prostate cancer risk. Discover how this tool empowers proactive health decisions.
Decoding BRCA Gene Mutations
Tumor-suppressor genes BRCA1/BRCA2 repair damaged DNA. Harmful mutations disrupt this process, causing:
- Breast cancer risk: 45-72% vs. 12% population average
- Ovarian cancer risk: 11-44% vs. 1.3% baseline
- Elevated risks: Pancreatic, prostate, and melanoma cancers
These mutations follow autosomal dominant inheritance – each child of a carrier has 50% inheritance probability.
Critical Risk Factors Analyzed
The calculator evaluates these evidence-based parameters:
Personal Medical History
- Early-onset cancers (<50 years)
- Bilateral breast cancer occurrences
- Triple-negative breast cancer diagnosis
- Ovarian/fallopian tube cancers
Familial Cancer Patterns
| Relationship | Cancer Type | Clinical Significance |
|---|---|---|
| First-degree | Breast <45 | High-impact indicator |
| Second-degree | Ovarian | Moderate risk elevation |
| Paternal line | Male breast | Highest hereditary link |
| Multiple relatives | Pancreatic | BRCA2 association |
Ancestral Risk Modifiers
- Ashkenazi Jewish heritage (founder mutations)
- Icelandic/Norwegian/Dutch ancestry
- Known family mutation carriers
How the Algorithm Calculates Your Risk
This validated model integrates:
- Bayesian probability frameworks
- Cancer penetrance data from 500,000+ cases
- Age-specific incidence tables
- Mendelian inheritance patterns
The system dynamically updates risk estimates as new family history emerges.
Interpreting Your Results
Risk stratification guides next steps:
Low Probability (<10%)
- Interpretation: Population-level risk
- Action: Standard age-appropriate screening
Moderate Probability (10-30%)
- Interpretation: Possible hereditary component
- Action:
- Genetic counseling referral
- Enhanced breast MRI surveillance
- Semiannual ovarian screening
High Probability (>30%)
- Interpretation: Likely mutation carrier
- Action:
- Diagnostic genetic testing
- Discussion of risk-reducing surgery
- Family testing coordination
Medical Management Pathways
Enhanced Surveillance Protocols
- Breast tissue:
- Annual MRI + mammography (25+ years)
- Contrast-enhanced spectral mammography
- Ovarian tissue:
- Quarterly CA-125 + HE4 biomarkers
- Semiannual transvaginal ultrasound
Risk-Reducing Interventions
- Pharmacological:
- Tamoxifen (50% risk reduction)
- PARP inhibitors for carriers
- Surgical:
- Bilateral salpingo-oophorectomy (80% ovarian risk reduction)
- Risk-reducing mastectomy (90% breast risk reduction)
Genetic Testing Procedures
When indicated:
- Pre-test counseling (45-minute session)
- Germline testing:
- Blood/saliva DNA sequencing
- Large rearrangement analysis
- Variant classification:
- Pathogenic vs. benign
- Variants of Uncertain Significance (VUS)
- Post-test management planning
Conclusion: Knowledge as Prevention
Understanding your hereditary cancer risk enables:
- Personalized screening regimens
- Evidence-based prevention strategies
- Informed family planning decisions
- Proactive management of future generations’ health
Assess your risk today to transform uncertainty into actionable health intelligence.
Disclaimer
This tool provides risk estimates only. Consult a healthcare provider for medical advice. Results do not constitute a diagnosis.
Frequently Asked Questions (FAQs) –
At what age should I assess my risk?
Begin 10 years before your family’s youngest diagnosis. Most start at 25.
What if my family history is incomplete?
Provide available details. The algorithm estimates probabilities based on partial data.
How accurate is this calculator?
Validation studies show 85-92% concordance with actual mutation status across diverse populations.
Can men develop BRCA-related cancers?
Yes. Male carriers face:
8% breast cancer risk (vs. 0.1%)
20% prostate cancer risk (vs. 12%)
Does insurance cover BRCA testing?
Most US/EU insurers cover testing when clinical criteria are met. GINA prohibits discrimination.
Add a Comment